The Brooklyn cast moves into the house and gets to know Red Hook. As the roommates struggle to figure out Katelynn's secret, JD slowly comes out to roommates and tries to create a gender friendly house.
As Ryan starts pursuing his music career, he tries to resist an attraction to his biggest fan, Baya. When Katelynn's boyfriend becomes distant, she starts flirting, drinking and trying to find herself.
Ryan attends memorial services at ground zero on 9/11. When Chet realizes that his dream of hosting TRL Live is impossible, he starts looking for other ways to promote his hosting career. When Scott breaks up with his girlfriend and starts playing the field, he has Devyn to answer to.
When JD takes the roommates to Gettysburg for an AIDS fundraiser, a modern day civil war breaks out between the guys and girls. Ryan shows off his hometown to his roommates. After finding out that she hasn't been "passing", Katelynn finally opens up to Ryan.
When Devyn's semi-fiancé visits, the guys convince her it is time to get real. When JD fails to resolve his differences with Devyn and Sarah, he teams up with the guys to pull a rat prank on the. Ryan's girlfriend, Belle, visits and the possibility of him getting redeployed for the Army resurfaces.
JD starts a new war in the house when the girls talk trash about the guys and refuse to do housework. Ryan decides to pursue his interest in filmmaking and starts taking classes at the NY Film Academy.
Chet struggles to prepare for an MTV hosting interview. When Katelynn starts feeling disrespected by Chet, she throws herself into an advocacy project and visits with her transgender friend, Jamie. Devyn gets an internship as a human hanger with the Jovani dress company.
When Katelynn's money problems lead her to take a cage dancing job and think about leaving the House, Scott challenges her to reassess her priorities. When the roommates receive an invitation to organize a screening for the new film about Pedro Zamora's life, they compete over who should control the project. SS starts aggressively pursuing his future as a Calvin Klein underwear model.
When Ryan begins to enjoy his life away from the military and the war, he starts opening up to the roommates about his issues only to find out at the last minute that he's being redeployed to Iraq. With Election Day 2008 nearing, the roommates take passionate political stances.
Ryan copes with the news of his redeployment to Iraq, crushed about having to put his goals, plans, and girlfriend Belle on hold. The Roommates take a trip to Atlantic City. Devyn acquires a puppy and gets a crash course in responsibility.
As the roommates pack to leave their Brooklyn home, the girls plan to give the Chet, Ryan, and Scott a taste of their own medicine by planning one last prank. When the boys suspect JD to be the instigator rather than the girls, the initially playful prank turns into a huge fight that threatens to cause a schism between the boys and the girls for good.