Joe Lando who played Byron Sully insisted on doing almost all his own stunts. He said doing his own stunt work made the character feel more real to him. In addition, Joe admitted some stunts such as eating worms and running on top of a moving train were things he would probably never have an opportunity to do again.
Two individuals played the character of Colleen Cooper: Erika Flores (S1-2) and Jessica Bowman (S3-END). Erika was asked to sign a 3-year contract after Season 2 however her father felt she should receive more money than her co-stars siblings. The network refused and recast Jessica Bowman as Colleen Cooper.
Jane Seymour, Joe Lando, Chad Allen and Shawn Toovey, in their DVD commentaries, all expressed interest in a future "Dr. Quinn" project. Only Allen declined to reprise his role in the two movies that continued the series after its cancellation.
Three of the cast members were born and raised in Illinois: Joe Lando who played Byron Sully was born in Chicago, Jim Knobeloch who played Jake Slicker was born in Belleville, and Frank Collison who played Horace was born in Evanston.
Jim Knobeloch who played Jake Slicker, was known as the prankster of the cast. One time he put horse manure in a person's pocket and another time, he put horse manure in Orson Bean (Loren Bray)'s hand as he slept.
In a 2015 feature on National Public Radio, Jane Seymour said that although she eventually came to think of "Dr. Quinn" as one of the projects she is most proud of in her career, she originally signed her contract for it (including both the TV-movie/pilot and a five-year series commitment) with only one night's notice-not because she had any particular interest in the show but because she had just discovered that her then husband/business manager had lost all her money and gotten her $9 million in debt. She had told her agent that to avoid losing her house and to protect her two young children, she would do any TV project available no matter what it was, and Dr. Quinn was the first one offered to her.
In the pilot, Jake Slicker was played by Colm Meaney, Mr. Loren Bray was played by Guy Boyd, & Robert E was played by Ivory Ocean. In the second episode until the series ended, Jake Slicker was played by Jim Knobeloch, Mr. Loren Bray was played by Orson Bean, & Robert E was played by Henry Saunders.
The trivia items below may give away important plot points.
Dr. Quinn was proposed to five times: David Lewis, Rev. Timothy Johnson, Dr. William Burke, Byron Sully, and Andrew Strauss/David Lewis (again). She said yes to David but then he was allegedly killed, turned down Rev. Johnson & Dr. Burke, and then said yes to Sully.
Rev. Timothy Johnson proposed to Michaela Quinn in order to adopt children from the orphanage train. She refused. He then proposed to the new school teacher, Louise Chambers. She accepted but Rev. Johnson broke it off when he discovered she didn't want children.