Dr. Mike and Sully return from their honeymoon and begin unpacking at their new homestead. A Boston banker comes to town and stirs up controversy among the townspeople as the inevitability of progress ensues.
Loren convinces the town to pay a baseball team to visit for an exhibition game against the town's team. The two teams will share the ticket sales, but problems arise when it's discovered Loren didn't read the fine print.
As Dr. Mike becomes increasingly absorbed in her romantic life with Sully, Colleen, feeling rebellious, joins her school friends in dangerous and questionable escapades. When Brian also begins to feel ignored, Mike and Sully realize how important it is to balance their new life.
Elderly Abner Foley comes to town looking for alternative treatment and a very friendly dog adopts Jake Slicker. The rest of the town looks forward to the costume party but first Brian must face a very big fear.
Dr. Mike injures herself after the other women have turned back on their quest to climb Pike's Peak. Sully steps in for his wife on the council to thwart Jake and Preston's casino plans. Grace, Myra, and Dorothy change their minds and head back up the mountain.
As the community prepares to celebrate Thanksgiving, Dr. Mike and Sully become anxious with their inability to conceive. As the couple try to get used to the idea of not having a baby, Jake becomes depressed about being alone.
Dr. Mike and her family receive an unexpected gift from Boston, a small poodle unsuited to life on the frontier. Brian has his first crush on Sara, Preston is embarrassed by a painful kidney stone, and the Pastor plans a living nativity.
As the town grows, a rowdier element is evident and the citizenry wants a little more law and order. Matthew believes he is suited for the job of sheriff but refuses to carry a gun which worries Dr. Mike.
When Ezra Leonard offers a $1000 reward to the capture-dead or alive- of the mountain man who kidnapped his son, Sully's rescue party turns into an unruly mob. Dr. Mike must accept help from Dr. Cassidy to save her pregnancy.
Dr. Mike, nearing her pregnancy's end, has her plans for scaling back interrupted when Cloud Dancing is stabbed and Emma needs an operation. Matthew wants Emma to leave Hank's employment when she's better.
Isabelle Maynard, an attractive painter, arrives in town attracting the eligible bachelors particularly Preston. But after the citizens learn Isabelle has leprosy they are determined to drive her out of town over Dr. Mike's objections.
Dr. Mike's mother and sisters arrive with a young Dr. Cook to deliver the baby. Conflict arises between Horace and Myra which ruins Preston's hotel groundbreaking. Sully works to prevent Cloud Dancing's transfer to another reservation.