Jovovich began modeling at the age of 12 when Herb Ritts photographed her for the cover of the Italian magazine "Lei". Photogapher Richard Avedon then featured her in Revlon's "Most Unforgettable Women in the World" advertisements.
In 1988, Jovovich had her first acting role in the television film "The Night Train to Kathmandu", followed by the feature film, "Two Moon Junction".
When she was fifteen, she starred in the 1991 feature "Return to the Blue Lagoon, then appeared in the 1997 feature "The Fifth Element" written/directed by Luc Besson. She also starred in Besson's "The Messenger: The Story of Joan of Arc" (1999).
In 2002, Jovovich starred in the horror feature "Resident Evil", adapted from the video game series of the same name, reprising her role in five sequels to date, including the upcoming "Resident Evil: The Final Chapter