Prior to filming, Director Peter Faiman, Writer and co-Producer John Hughes, and Producer Richard Vane took a road trip throughout Georgia, The Carolinas (North and South), Mississippi, and Tennessee to scout the route of the film's characters, Dutch Dooley and Doyle would take to drive back home to Chicago for Thanksgiving. Faiman liked most of the places that he'd seen during the trip, and they ended up in final film.
The large double doors, out of which Dutch bursts, are supposed to be the doors of Doyle's dormitory. In reality, these doors are the main entrance to Hermann Hall, the administration building at Berry College, where the school scenes were filmed.
If you pause it just right when Dutch is going through his wallet in the motel room, you can get a clear shot of his drivers license showing his address and name, which reads "David Dooley." Which means "Dutch" must be a nickname. There's never an actual mention of "David" in the film.
Tim Allen was in consideration for the role of Dutch Dooley, but was busy shooting Home Improvement (1991). Dan Aykroyd, James Belushi, Robin Williams, John Goodman, Bill Murray, Steve Martin and Chevy Chase were also considered.