
| Swoosie Kurtz | ... | Alexandra 'Alex' Reed Halsey Barker (127 episodes, 1991-1996) |

| Patricia Kalember | ... | Georgiana 'Georgie' Reed Whitsig (127 episodes, 1991-1996) |

| Sela Ward | ... | Theodora 'Teddy' Reed Margolis Falconer Sorenson (127 episodes, 1991-1996) |
 | Elizabeth Hoffman | ... | Beatrice 'Bea' Reed Ventnor (127 episodes, 1991-1996) |
 | Garrett M. Brown | ... | John Whitsig (100 episodes, 1991-1996) |
 | Julianne Phillips | ... | Francesca 'Frankie' Reed Margolis (93 episodes, 1991-1996) |

| Heather McAdam | ... | Catherine 'Cat' Margolis (80 episodes, 1991-1996) |

| Ed Marinaro | ... | Mitch Margolis (75 episodes, 1991-1994) |
 | Dustin Berkovitz | ... | Evan Whitsig (45 episodes, 1991-1996) |

| Ryan Francis | ... | Trevor Whitsig (43 episodes, 1991-1996) |
 | Jill Novick | ... | Teenage Teddy (39 episodes, 1991-1996) |
 | Sharon Martin | ... | Teenage Alex (37 episodes, 1991-1996) |
 | Riff Regan | ... | Young Georgie (34 episodes, 1991-1996) |

| Ashley Judd | ... | Reed Halsey (32 episodes, 1991-1994) |
 | Sheila Kelley | ... | Dr. Charlotte 'Charley' Bennett (28 episodes, 1995-1996) |
 | Robert Klein | ... | Albert 'Big Al' Barker (25 episodes, 1993-1996) |
 | Tasia Schutt | ... | Little Frankie (22 episodes, 1991-1994) |
 | Philip Sterling | ... | Judge Truman Ventnor (20 episodes, 1991-1995) |

| Paul Rudd | ... | Kirby Philby (20 episodes, 1992-1995) |
 | David Dukes | ... | Wade Halsey (19 episodes, 1991-1993) |

| Nora Dunn | ... | Norma Lear (19 episodes, 1993-1996) |

| George Clooney | ... | Detective James Falconer (19 episodes, 1993-1994) |
 | Mark Frankel | ... | Simon Bolt (18 episodes, 1992-1993) |
 | Jo Anderson | ... | Dr. Charlotte 'Charley' Bennett (15 episodes, 1994-1995) |

| Stephen Collins | ... | Dr. Gabriel 'Gabe' Sorenson (15 episodes, 1995-1996) |

| Joe Flanigan | ... | Brian Kohler-Voss (15 episodes, 1995-1996) |
 | Peter White | ... | Dr. Thomas Reed (14 episodes, 1991-1996) |

| Noelle Parker | ... | Reed Halsey (13 episodes, 1995-1996) |
 | Eric Close | ... | William 'Billy' Griffin (12 episodes, 1995-1996) |

| Daniel Gerroll | ... | Dr. David Caspian (11 episodes, 1994-1995) |
 | Duane Davis | ... | McKinley (10 episodes, 1992-1993) |

| John Wesley Shipp | ... | Lucky Williams (10 episodes, 1994-1995) |
 | Sean Nelson | ... | Jesse Bayliss (9 episodes, 1995-1996) |

| Jill Boyd | ... | Little Frankie (8 episodes, 1994-1996) |
 | David Gianopoulos | ... | Victor Runkle (7 episodes, 1991-1992) |

| Michael Whaley | ... | Dr. Wesley 'Wes' Hayes (7 episodes, 1995-1996) |

| Josh Lozoff | ... | Teenage Mitch (6 episodes, 1991-1993) |
 | Kathryn Zaremba | ... | Roxie Whatley (6 episodes, 1994-1995) |

| Ron Fassler | ... | Barry Gold (5 episodes, 1991-1994) |

| Kathy Wagner | ... | Reed Halsey (5 episodes, 1991) |

| Dan Gauthier | ... | Kyle Parks (5 episodes, 1993) |
 | Gili Lang | ... | Little Trevor (5 episodes, 1995-1996) |
 | Gregory Harrison | ... | Daniel Albright (5 episodes, 1995) |
 | Sidney Chankin | ... | Reginald / ... (4 episodes, 1991-1993) |

| Steve Vinovich | ... | Rupert Coates (4 episodes, 1991-1993) |
 | Franc Luz | ... | Hank Seawell (4 episodes, 1991) |

| Carmen Argenziano | ... | Captain Smiley (4 episodes, 1995-1996) |
 | Bruce Weitz | ... | Pug Finnegan (4 episodes, 1996) |

| Stacy Arnell | ... | Janet (3 episodes, 1995-1996) |

| Cliff Bemis | ... | Fred Tuttwyler (3 episodes, 1991-1993) |
 | Mark Patrick Gleason | ... | Young Wade (3 episodes, 1991-1992) |
 | Tuc Watkins | ... | Brad (3 episodes, 1991-1992) |
 | Jennifer Savidge | ... | Marissa Stone (3 episodes, 1992-1996) |
 | Ryal Haakenson | ... | Man entering courthouse / ... (3 episodes, 1992-1993) |
 | Mary Donnelly-Haskell | ... | Fran Neuswanger (3 episodes, 1992) |
 | Matthew Faison | ... | Dr. Stammreich / ... (3 episodes, 1993-1994) |
 | Charlotte Rae | ... | Mrs. Gump (3 episodes, 1994-1995) |

| John Del Regno | ... | Eddie Voskobynik (3 episodes, 1994) |

| Susan Beaubian | ... | Ellen Jeffries (3 episodes, 1995-1996) |
 | Philip Casnoff | ... | Jack Chambers (3 episodes, 1995) |

| Cully Fredricksen | ... | Detective Grant (3 episodes, 1995) |
 | Jacob Loyst | ... | Little Evan (3 episodes, 1995) |

| Michael Tomlinson | ... | Dr. Howard Weber (3 episodes, 1995) |
 | Bette Rae | ... | Guard / ... (2 episodes, 1991-1996) |
 | Doris Belack | ... | Naomi Margolis / ... (2 episodes, 1991-1995) |

| Greg Collins | ... | Joe the Trucker / ... (2 episodes, 1991-1995) |

| Peggy Pope | ... | Mrs. Frawley / ... (2 episodes, 1991-1994) |
 | Carole Androsky | ... | Female Shopper / ... (2 episodes, 1991-1993) |
 | Lewis Dauber | ... | Ed Farrell / ... (2 episodes, 1991-1993) |
 | George Furth | ... | Mr. Rattner (2 episodes, 1991-1993) |
 | Dori Brenner | ... | Maggie D'Amato (2 episodes, 1991-1992) |
 | Tom Isbell | ... | Max Weldon (2 episodes, 1991-1992) |
 | Philip Brown | ... | D.C. (2 episodes, 1991) |
 | Patrick Husted | ... | Fan #1 (2 episodes, 1991) |

| Kim Johnston Ulrich | ... | Tiffany Blue (2 episodes, 1991) |
 | Lenny Wolpe | ... | Dr. Reinholdt (2 episodes, 1991) |
 | William Katt | ... | Jeffrey Teller (2 episodes, 1992-1993) |

| Shelley Morrison | ... | Juanita (2 episodes, 1992-1993) |

| Michael Laskin | ... | Rabbi Chasan (2 episodes, 1992) |
 | Leonard Stone | ... | Harmonica Man (2 episodes, 1992) |
 | Heidi Swedberg | ... | Jill Parkins (2 episodes, 1992) |
 | Paul Hayes | ... | Delivery Man / ... (2 episodes, 1993-1996) |
 | David Dunard | ... | Mr. Feldgrabber / ... (2 episodes, 1993-1995) |

| Doug Ballard | ... | Detective Ray (2 episodes, 1993-1994) |
 | Stephen Taylor Knot | ... | Casey Falconer (2 episodes, 1993-1994) |
 | LuAnne Ponce | ... | Young Frankie (2 episodes, 1993-1994) |
 | Lomax Study | ... | Mister Jaques (2 episodes, 1993-1994) |

| Kirsten Dunst | ... | Kitten Margolis (2 episodes, 1993) |

| Henry Gibson | ... | Cyrus Calhoun (2 episodes, 1993) |

| Sal Viscuso | ... | Harold J. Wise (2 episodes, 1993) |
 | Philip Attmore | ... | Marcus (2 episodes, 1994-1995) |
 | Elizabeth Franz | ... | Gladys Lear (2 episodes, 1994-1995) |
 | Robert Kerbeck | ... | John McCormick (2 episodes, 1994-1995) |

| Kymberly Newberry | ... | Case Worker / ... (2 episodes, 1994-1995) |

| Daphne Ashbrook | ... | Maggie Falconer (2 episodes, 1994) |

| Jeff Austin | ... | Det. Robert Nash (2 episodes, 1994) |
 | Tsai Chin | ... | Rita Kwan (2 episodes, 1994) |

| Isabella Hofmann | ... | Abby Malker (2 episodes, 1994) |
 | Tammy Lauren | ... | Evelyn Barrington (2 episodes, 1994) |
 | Caroline McWilliams | ... | Grace Watley (2 episodes, 1994) |
 | Richard Robert Redlin | ... | Devon Williams (2 episodes, 1994) |
 | Charles Hallahan | ... | William 'Will' Griffin, Sr. (2 episodes, 1995-1996) |
 | Julie Kryder | ... | Young Charley (2 episodes, 1995-1996) |

| John D. LeMay | ... | Professor Jacobsen (2 episodes, 1995-1996) |
 | Shira Roth | ... | Georgie at Six (2 episodes, 1995-1996) |

| Gilles Savard | ... | Maitre D' (2 episodes, 1995-1996) |
 | Maxxe Sternbaum | ... | Little Reed (2 episodes, 1995-1996) |
 | Norris Young | ... | Nelson Bayliss (2 episodes, 1995-1996) |

| Tom Amandes | ... | Martin (2 episodes, 1995) |
 | Erich Anderson | ... | Greg LeMott (2 episodes, 1995) |
 | Kirk Baily | ... | The Creep (2 episodes, 1995) |
 | Gabrielle Boni | ... | Little Charley (2 episodes, 1995) |
 | Darrell Larson | ... | Kenny Stepinek (2 episodes, 1995) |
 | Mark Lonow | ... | Dirk Abromowitz (2 episodes, 1995) |
 | Tamlyn Tomita | ... | Kiri Adams (2 episodes, 1995) |
 | K. Todd Freeman | ... | Chardonnay / ... (2 episodes, 1996) |

| Jesse D. Goins | ... | Walter Livingston (2 episodes, 1996) |

| Vince Grant | ... | Dr. Ben Tracks (2 episodes, 1996) |
 | Joyce Guy | ... | Evelyn Livingston (2 episodes, 1996) |
 | Ed Williams | ... | Minister (2 episodes, 1996) |