Commander Hoek and Cadet Stimpy are sucked into the hideous vortex of a black hole. Now as inhabitants on a new planet, and constantly mutating, the pair solve an age-old mystery after being tipped-off by a familiar smell. Next, Stimpy in his naive optimism, invents an emotion-controlling helmet. Ren, whether he likes it or not, is now the involuntary test-subject.
Ren and Stimpy join the Army, where they begin basic training under a very demanding Drill Sargent. We then follow the unusual and bizarre adventures of "Powdered Toast Man" as he is called on for various rescue missions.
Ren and Stimpy find themselves amid the Wild West, where they run up against a Sheriff and Deputy who's favourite past-time is hanging people. They then hit the road as salesmen, going door-to-door to sell Rubber Nipples.
Convinced that wrestling is all an act, Mad Dog Höek (Ren) and Killer Kodoogan (Stimpy) are thrown into the wrestling ring for a bout against the enormous Lout Brothers, Lump and Loaf. Next, we see the Ren and Stimpy spend "the next twelve minutes" inside a mansion haunted by a shy, depressed and thoroughly non-scary Casper-like ghost.
Ren & Stimpy, starving, exploit the benefits of living as babies. Then, George Liquor American takes us the Dog Show, where Ren & Stimpy are pitted against some tough competition. But only George can handle the judge's harsh scrutiny.