Former child star "Poofie" McGuire comes to the hospital to research a role for an upcoming sitcom, and he proceeds to irritate the entire staff. Meanwhile, Julie tries to locate the brother of a dying man, and Dr. Riskin is pursued by an obnoxious mother whose son is suffering from high blood pressure.
Strangeness abounds during the full moon. Jeff encourages his co-workers to pursue their romantic fantasies; an astronaut arrives with a lump on his head; and Blanche Devereaux ("The Golden Girls") seeks Dr. Riskin's advice about a sexual problem.
The second season opens and the staff (which no longer includes Dr Riskin or Greg) learns that a tycoon is sentenced to community service in the hospital. Meanwhile, Hank tries to win over Gina and there's a strange new nurse named Luke.