Sandy encourages one of her patients to become romantically involved with another patient, who happens to be Greg's grandfather. Greg's grandfather dies during a romantic encounter, and Sandy is the target of Greg's scorn.
Former child star "Poofie" McGuire comes to the hospital to research a role for an upcoming sitcom, and he proceeds to irritate the entire staff. Meanwhile, Julie tries to locate the brother of a dying man, and Dr. Riskin is pursued by an obnoxious mother whose son is suffering from high blood pressure.
Strangeness abounds during the full moon. Jeff encourages his co-workers to pursue their romantic fantasies; an astronaut arrives with a lump on his head; and Blanche Devereaux ("The Golden Girls") seeks Dr. Riskin's advice about a sexual problem.