According to the series pilot, the character 'Six' was named because of the number of beers her parents drank the night of Six's conception. This minutiae was downplayed later in the series, referring to her birth order instead.
In the Big Bang Theory episode 'The Bar Jar Conjecture' Raj suggests getting the girl who played TV's Blossom, to join their team in the science quiz, in which they're going up against Sheldon. The girl who plays Blossom (Mayim Bialik) is the same girl who plays Amy, Sheldon's girlfriend.
The theme song for the pilot episode was "My Prerogative" By Bobby Brown. In that episode, you can look closely and see Blossom dancing slower and lip synching to the song. The credits are also different, it also included Jenna Von Öy's name.
The character of Nick Russo was inspired by legendary rocker Dion DiMucci. Creator Don Reo was friends with Dion and admired his relationship with his kids. Reo was also inspired by J.D. Salinger's classic novel "The Catcher in the Rye" and wanted to make a version for girls.
Blossom has two parents in the pilot. The dad was played by One Day at a Times' Richard Masur, not Ted Wass, the mom was played by It's a Living's Barrie Youngfellow. The dad was an accountant at a Los Angelos corporation, not a musician, and his pet name for Blossom was "ace". Joey Lawrence's name in the pilot was "Donnie." And the theme song was "My Prerogative" by Bobby Brown, not "My Opinionation".
Though the original concept of the show was for Blossom to have a hip, single musician dad the executives insisted she have two parents in the pilot. After a great deal of fighting with show producers the network caved and the show went back to the original idea, casting Ted Wass as Blossom's single musician dad.
Mayim Bialik is an advocate of Attachment Parenting, and she wrote a book about it. That is natural childbirth, extended breastfeeding, and sleeping with children ( in the same room) during their formative years.
Mayim Bialik admits she did not shave her legs when she was on Blossom. Joey Lawrence used to tease her relentlessly about it. In fact Mayim still doesn't shave her legs, or armpits. She never did either.