According to the series pilot, the character 'Six' was named because of the number of beers her parents drank the night of Six's conception. This minutiae was downplayed later in the series, referring to her birth order instead.
In the Big Bang Theory episode 'The Bar Jar Conjecture' Raj suggests getting the girl who played TV's blossom, to join their team in the science quiz, in which there going up against Sheldon. The girl who plays blossom is actually the same girl who plays Amy, Sheldon's girlfriend.
The Theme Song My Prerogative By Bobby Brown. In the pilot episode, you can look closely and see Blossom dancing slower and lip synching to the song. The credits are also different, it also included Jenna Voy On's name.