The producers wanted to have all the voice actors from the first Rescuers film reprise their roles of their respective characters for the sequel. However, in the original Rescuers film, the albatross Orville was voiced by Jim Jordan, who died two years before this film released. There were no voice replacements for Jordan, so Orville was replaced with the character's brother Wilbur, voiced by John Candy. This is a reference to the Wright brothers, Orville and Wilbur, the inventors and pilots of the first functional airplane.
This was the first 100% digital feature film ever made. The animation and backgrounds were done traditionally but all of the coloring, many effects, and the final film printing was all done digitally. This was the first film produced with Disney's Academy Award-winning "CAPS" production system, developed for the film. It cut the production time for an animated movie down by at least six months.
On its initial release, this film was preceded by the Mickey Mouse short subject The Prince and the Pauper (1990). Interestingly enough, this was only the second Mickey Mouse short made since the 1950s, with the first being Mickey's Christmas Carol (1983), which was made to accompany the 1983 re-release of The Rescuers.
Of all the things McLeach calls Joanna as an insult (four-legged python, salamander, etc,) he never once refers to her as her actual species, a goanna (a monitor lizard found in Australia and southeast Asia).
The least successful film released during the Disney Renaissance. After the poor opening weekend, box office Disney executive Jeffrey Katzenberg ordered all television advertisements for the film pulled. This film opened on the same weekend as another film to star John Candy, Home Alone (1990), which went on to gross more then ten times then The Rescuers Down Under did; a reason for the marketing for it was pulled by Disney. The financial failure of this feature discouraged Disney from releasing later animated sequels theatrically.
The only film released during the Disney Renaissance to not be a musical. Second Disney animated film not to be a musical, though it is worth mentioning that McLeach and Wilbur both sing incidental songs while none of the characters in The Black Cauldron (1985) (the first) sing.
The first animated film to have the appearance of "multi-plane shots" with the use of computer layering and formatting as opposed to manually producing the shots with multi-plane cameras (previous Disney films had no multiple-plane shots or only two-plane shots).