The screenplay for this movie was mentioned in the same June 1985 "New York Magazine" article about Emilio Estevez and his then-frequent costars that coined the term "The Brat Pack" for that group of actors. At that time, the screenplay's title was "Clear Intent."
Charlie Sheen pulled a prank on Emilio Estevez by saying that he had punched a paparazzo in a restaurant on the night before filming. Sheen took it further by having an on-set police officer who was working security arrest him for assault while he was filming a scene. Estevez was stunned until Sheen returned laughing.
Charlie Sheen previously played Chris Taylor in Platoon (1986). In Men at Work he plays Carl Taylor. A "grunt" that gets paired up with yet another crazed Vietnam vet in Keith David (I)'s character, Louis Fedders.
The restaurant where Carl and James eat lunch is called Good Stuff. There are three locations in the Los Angeles area - they filmed at the location in Hermosa Beach on The Strand, which James mentions during lunch as a desired location for the surf shop he and Carl dream of opening.