At theatrical showings in Monterrey, Mexico, women in the audience were given envelopes marked "Solo para mujeres" (for women only) containing tissues.
The role of Oda Mae Brown was not written with Whoopi Goldberg in mind, but Patrick Swayze, an admirer of hers, convinced the producers that she would be right for the part.
When Sam follows Willie to his apartment, he learns that his surname is 'Lopez' from the name tag on the apartment call button. Sam passes this information on to Oda Mae. However, the name 'Lopez' is a 'Dynotape sticker' obscuring the real name of the occupier. This probably explains why 'Willie Lopez' has no police record when Molly passes this information on to the Police detective.
Shortly before production began, Whoopi Goldberg was not sure that she was going to be able to put this movie into her work schedule. The part was then verbally offered to Jackée Harry who accepted. However, at the last minute Goldberg was able to do the film and Harry was dropped.
The subway scenes were filmed on the abandoned lower level of the 42nd St. station of the IND 8th Ave. line. Trains appearing in the film wrong-railed through the station; that is, they ran in the opposite direction of normal operation.
Molly tells Sam that he "leads a charmed life." This is a line from William Shakespeare's Macbeth. Macbeth also claims to lead a charmed life - meaning he cannot be killed. Immediately after making this claim, however, he is killed. Sam is killed after seeing a production of Macbeth.
When passing through solid objects, ghosts appear to absorb some of the material they are going through. Jerry Zucker had some difficulty explaining what he wanted this effect to look like. Finally, he illustrated it by dipping a napkin into coffee.
Vincent Schiavelli's ghost character breaks open a cigarette machine and longs to be able to have another smoke. In real life, Schiavelli would later die of lung cancer.
Bruce Joel Rubin wanted Patrick Swayze to play Sam Wheat after he saw an interview Swayze gave. When he brought up his father, he burst into tears. Rubin thought if a macho guy like Patrick Swayze could cry over a loved one, he'd be perfect for Ghost.
Patrick Swayze alleged that Sam Wheat was the hardest role he ever played in his career, mainly because he had to be an observer to the action, and not a participant.
Bruce Joel Rubin didn't like the idea of the Dark Spirits having faces and hands. He thought they should have looked more like shadows come to life, not ghouls with human features.
The song Sam sings relentlessly to Oda Mae to get her to agree to help him is "Henry the 8th, I Am". The lyrics, in part, are "She wouldn't have a Willie or a Sam..." Patrick Swayze's character is named Sam, and the man who murdered him is named Willie.