A joint American/English production, the first 14 episodes were produced entirely in England. When the English backers dropped out, the production moved to Los Angeles, all of the English supporting cast were dropped, Dr. Ian Matheson became an occult talk-show host, and the show was renamed "Love and Curses".
According to Lee Goldberg in an article in Comics Scene#46, at one point, the producers planned on producing a companion series involving vampires for She-Wolf of London. That series would have featured Blade, the vampire hunter later played by Wesley Snipes, as a globetrotting vampire hunter. However, these plans got scuttled.