It was later revealed in the show about the connection to the popular video game. The events of the show take place about twenty years after the time frame of the video game. Fred Edison is the son of the character Weird Ed. It is believed he was named Fred after the character of Dr. Fred. Like his grandfather, Fred Edison is also a doctor, although it is unsure what his doctorate is in. It is believed by now the characters in the game are presumably deceased and have willed the mansion and its scientific equipment to Fred Edison
Based on a popular "point and click adventure" computer game with the same name although, besides the character Fred Edison, the game and the TV series doesn't have any connection between them. They don't even share the same plot or storyline.