A family of four is brutally murdered. The investigation leads detectives to "horrorcore" culture, an accomplice who claims to have suffered from amnesia, and an accused killer with an unlikely post-traumatic stress disorder defense.
Two teens from an underachieving high school are accused of burning to death a student from a more successful charter school, and Lupo and Bernard suspect that their principal is providing them with a phony alibi.
Is a graduate student working in the medical lab at a prestigious university robbing and killing female escorts to support his gambling addictions? And how far will his loyal fiancée go to protect him?
Cutter is forced to play hardball with his mentor after her Innocence Project group gets his guilty verdict in a murder trial set aside, but is he ready to handle the unexpected consequences of his actions?
When an environmental scientist, Dr. Oscar Silva, is poisoned during a global warming symposium, Detectives Cyrus Lupo and Kevin Bernard initially suspect competitors from Dr. Silva's field of study. It is soon discovered that Dr. Silva is involved in a messy custody battle with his wife's ex-husband, Phillip Shoemaker and the focus of the investigation quickly shifts to the victim's family. Meanwhile, the case becomes personal for Cutter as it stirs up unpleasant memories from his own past.
A 20-year-old is accused of killing his sister after they crashed the mayor's black-tie party, but detectives also soon find unexpected links between the suspect and the office of a New York senator who was also at the party.
Lupo and Bernard uncover a possible conspiracy to kill off wealthy cancer patients in the calendar year 2010 so that their inheritors don't have to pay an Estate Tax, but legal roadblocks make the case difficult to prosecute.
A fatal stabbing leads to the discovery that a bio-research firm has been exploiting the cells of an African American man who died 50 years ago for medical research, but has never compensated his dirt-poor descendants.
Detectives suspect that a tacky and volatile wife murdered her husband, but they soon discover that the victim may have backed out of a conspiracy with fellow husbands to hide assets from their wives until their divorces.
Lupo and Bernard believe they are in a race against time to find a student threatening on an Internet blog to blow up a school--only to discover that they are looking for a disgruntled teacher instead.