Keenen Ivory Wayans left the show in the middle of the fourth season over disputes with Fox about censoring the show's content and rerunning early episodes without his consultation. At the end of the season, Kim Wayans, Shawn Wayans and Marlon Wayans followed their brother in leaving the show. Damon Wayans had already left the show at the end of the third season to pursue his film career.
Ugly Wanda, played by Jamie Foxx, was based on a character LaWanda Page played in a sketch on Redd Foxx (1977). The first sketch to feature Wanda, in which she gives an erotic massage to a man who hasn't seen her face, is a remake of the original sketch. The character was named after Page. Jamie took his stage name as a tribute to Redd Foxx.
For the first few episodes, an exotic-looking logo was used for the opening credits. After the band Living Colour claimed the show stole the logo from them and threatened to sue, the logo was changed to one with rather plain-type letters.
Martin Lawrence auditioned for a role on the show but didn't get cast and a few years later on the show Martin Tisha Campbell played his wife and then went on to play In Living Color star Damon Wayan's wife on My Wife and Kids