On the first day of production, the producers sent Steven Soderbergh a telegram, joking that they'd heard reports that he couldn't direct traffic. Twelve years later, Soderbergh won an Oscar for directing Traffic (2000).
One scene includes a videotaped confession by one of James Spader's character's past lovers. The director gave the script and a video camera to Jennifer Jason Leigh so she could tape the speech at home with the help of her boyfriend. They never got around to it; once filming began, a crew member was used in the brief role.
The trivia item below may give away important plot points.
Steven Soderbergh gave the producers a list of possible film titles, including: "46:02", "Retinal Retention", "Charged Coupling Device", "Mode: Visual", "Sex, Lies, and Videotape", and "Hidden Agendas". Soderberg heavily favored "46:02" (the supposed running time of the tape Ann makes for Graham; the running time appears in the script but not in the final film), but the producers chose "Sex, Lies, and Videotape" immediately. In a Q&A session after a screening in 1989, one audience member advised Soderbergh that he would "have to change" the title, which he considered terrible.