Actresses Meryl Streep and Roseanne Barr share only one major scene in the movie: at the beginning, when Roseanne's character spills wine on Mary Fisher's dress, thus introducing her husband to Mary, and setting the entire plot of the movie in motion.
Prior to this picture, considered Meryl Streep's first ever full comedy feature film, the closest thing to full comedy movies that Meryl Streep had appeared in, were the comedy-drama Heartburn (1986) and the romantic-comedy drama Manhattan (1979).
The film is dedicated to Dean E. Maitland. The film's dedication at the end of the closing credits states "In loving memory of Dean Maitland 1970-1989". Maitland worked as a sound recordist on the movie.
The tombstone for Mary Fisher's dog reads, "Ma Juliet Chérie 1981-1989 - Tu seras toujours dans mon coeur," which, when translated from French to English, reads, "My Cherished Juliet 1981-1989 - You Will Always Be In My Heart".
Second filmed adaptation of Fay Weldon's novel "The Life and Loves of a She-Devil". The first version, The Life and Loves of a She-Devil (1986), had been made for TV, and broadcast three years earlier in 1986. A third filmed adaptation, an Indian remake version in Tamil/Telugu, Sathi Leelavathi (1995), debuted in 1995, about six years after this picture launched. A fourth filmed adaptation, another Indian remake version, but this time in Hindi, called Biwi No. 1 (1999), debuted around four years after the first Indian remake, and about a decade after She-Devil (1989).
Actress Meryl Streep) considered for a time playing the "She-Devil" character herself but due to some conceptual similarity with Streep's then previous picture A Cry in the Dark (1988), Streep decided to portray romance novelist Mary Fisher instead.
During the first dinner scene with Mary Fisher, her mother, Bob Patchett, and his kids, Mary's mother reveals that Mary is really 41 years old when Mary herself claimed to be 34. (Meryl Streep) herself was actually 39 when filming of She-Devil (1989) began, and turned 40 on June 22nd, 1989, during the film's production.
This cinema movie was made and released about three years after the first version of the film's source book, the four hour The Life and Loves of a She-Devil (1986) mini-series, had been first broadcast on UK television in 1986.
There was a title similarity between this feature film and actress Meryl Streep's previous picture A Cry in the Dark (1988). Both titles had a word associated with demonology, "Devil" with this movie and "Evil" with the earlier film. Further, the words "She" and "Angels" are both associated with the female gender. Moreover, Streep would also go on to star in two later productions with titles where two of these words would appear again, in Angels in America (2003) and The Devil Wears Prada (2006).
The customized license plate on romance novelist Mary Fisher (Meryl Streep)'s Rolls Royce luxury car reads "AMOUR". The customized licence plate on accountant Robert Pratchett (Ed Begley Jr.)'s car states "ASSETS".