In the opening scene at the ballpark, the base runner has a decided limp because he pulled his hamstring on one of the first dozen takes of the shot. The shot in the film is one they settled on after approximately 20 takes, due to the fact that the hitter was unable to hit the ball into center field. The hitter was a college player, not a professional as originally dictated to the casting department.
The movie was filmed in Central and Northern Florida. The shopping center where the photo booth is standing is in College Park, Florida. The photo booth was constructed for the movie. The Showbiz pizza is located in Altamonte Springs, Florida and is still there, except it is now, like all Showbiz pizzas, Chuck-E-Cheese. Kevin's birthday party was filmed at The Mystery Fun House in Orlando, Florida.
According to Ron Howard in an interview with "The Directors", the scene where Helen discovers the nude pictures, was actually an incident that happened to producer Brian Grazer.
When Gil and Karen are riding in the van prior to the crash, they are driving on Kirkman Road in Orlando, Florida.
The film grossed just under $100 million during the original run in theaters. Several years later, the project was rereleased into theaters so it could be logged officially as earning $100 million.
When Grandma inhales the helium balloon and says that when she was born, Grover Cleveland was president. 'Helen Shaw' (the actress who played her) was born on July 25, 1897, just four months and three weeks after the end of Cleveland's second term.
In the scene where Steve Martin and Mary Steenburgen are fighting over the fact that she is pregnant, Steve says "...Lets just have a dozen and act like they are donuts." In the movie Cheaper by the Dozen (2003) he plays the father of a dozen children.
In the scene where Gil and Karen are going to Kevin's school to speak to the Principal, the school is 'Gerald Paris Elementary School'. A homage to Jerry Paris, who directed 42 episodes of _"Happy Days" (1974)_ .
According to the interview in the DVD extras with composer Randy Newman, the soundtrack song "I Love to See You Smile", which is perhaps his most beloved, was written with Mary Steenbergen's smile in mind.