When Doogie decides to get his own place, he and his parents go look at some apartments but none of them is to his liking. But when he finds a loft, he feels this is it but his father refuses to support him if he decides to take it.
Doogie is planning his New Year's celebration. He comes home and finds a girl there. He learns that the man who rented him his place also rented it out to her. They try to live together but the girl is very fancy free which drives the uptight Doogie crazy.
Vinnie is upset when his not yet divorced father starts dating another woman. David is offered the position of Head of Family Medicine at the hospital.
After Vinnie loses his virginity to Laura, he feels not good enough for her and begins to behave erratically. Doogie treats a famous actress for a mysterious illness.
Vinnie serves on a jury and angers the other jurors by casting the only dissenting vote. Doogie finds out that a well-respected doctor has never gotten his medical license.