Dylan amazingly survives the two huge explosions, and escapes from the boat with major burns. He makes his way to shore, unaware Zoe is still dragged under the water and drowning from the weight of her dress. Charlie dives in to save her, but the freezing water causes Charlie to suffer a massive heart attack. Is this the end for the much-loved nurse? Duffy returns to the ED as an agency nurse, while Louise fights to save couple's child.
Connie fights to save Charlie's life as he continues to flatline in Resus. Rita tries to persuade Connie to give up on Charlie, but she refuses and eventually the nurse's life is saved. Louise is inspired by Duffy and decides to quit her receptionist job and become a nurse. Gang violence spills into the hospital leaving no one safe.
Louise begins her first shift as a nurse, but she struggles to find her feet. A woman with Objectum Sexuality leaves Cal and Dylan baffled, while Iain has an assault complaint lodged against him by a traffic warden. Honey calls things off with Ethan.
Alicia Munroe, a new Geordie F2 junior Doctor begins her first shift and is paired up with Lily for her first shift. Together, they work on a pregnant mother who crashes her car after attacking her social worker. Dylan and Lofty bond over a patient, and Honey decides to leave Holby City and begin a new business elsewhere.
An attack on a room full of racist supporters leads to chaos in the ED when the victims are brought in along with the perpetrator and, when the situation escalates further, the police instigate an evacuation, with Jacob ending up in the firing line.
Dixie and Iain are called out on a HART training day, but things soon get real when they're called out to a male who is trapped under a fallen chimney. At the same time, Dixie meets HART Paramedics Jess Cranham. Jess later asks Dixie out on a date.Lofty and Dylan work together on an accident prone woman.
Lily receives a phone call from her mother - her father died peacefully overnight. Struggling to come to terms with the news, she takes her anger out on patients. Cal and Iain suffer injuries when a platform collapses at a warehouse. Cal thanks a young woman, Ruby, for saving his life from being crushed by a crate, and offers to take her out on a date, but just as he does fraudster Taylor Ashbie returns with big news - she's given birth and the baby is his.
Lily throws herself back into work hours after her father's funeral, but overwhelmed with emotions she lashes out at a patient refusing a chest drain because of a rare medical condition. Dixie opens up about her rejection to adopt by the adoption board. Cal names his new daughter Matilda.
Following the shooting, Jacob recovers well and decides to go for a run in the forest, but he discovers a man in a tent and admits him to the ED. Once there, he convinces Connie he is fit to work. He treats a harassed teacher and helps him realise he's suffering withdrawal symptoms from alcoholism. Lily makes a mistake realigning a male's dislocated broken ankle leaving Alicia no choice but to stand in and save him from further complications, straining Lily and Alicia's working relationship even further.
Jacob prepares to take action against the police officer who shot him by getting his name - can Connie's wise words make him see sense in time? Alicia impresses Connie and she encourages the junior doctor to take her exams as soon as possible, and when Connie asks for a senior doctor to write up a report on Alicia, it's Lily who offers. Lily later falsely raises concerns to Connie after becoming jealous when Alicia successfully performs a tricky procedure. Cal and his daughter continue to bond.
Alicia suffers a horrifically traumatic day when a young boy she's looking after disappears. As she ventures into the ambulance station, she comes face-to-face with a violent scene. She shows her instincts and takes the injured man to safety to treat him. She proves herself an exceptional doctor, but both Lily and Connie express their disappointment towards her leaving the hospital. Lily's bullying towards Alicia reaches a whole new level and after a traumatic day - Alicia hands in her notice and departs Holby City.
Iain and Dixie are called to the woodlands where they discover HART Paramedic Jess Cranham has fallen down a deep hole. At the scene is her girlfriend and daughter. Dixie become suspicious back at the hospital as she learns Jess is on anti-depressants, but Iain tells her not to intervene. Lily becomes isolated as the team learn of her bullying towards Alicia. Matilda is brought into the ED by a paranoid Cal - and his heart is later broken as he learns he is not Matilda's biological father.
Cal receives the shock of his life as he learns he was adopted. Devastated by the two bombshells dropped on him, he hands Matilda over to social services. A gay couple have their wedding day torn apart when the venue collapses. Jacob deals with an uncooperative patient.
Dixie and Iain are left injured when the ambulance skids on the ice and falls to its side. Connie and Jacob end up sleeping together after working together for the day on treating an injured casualty in the back of the ambulance. New receptionist Jack Diamond arrives at the Emergency Department, and finds Christmas spirits are low.
Connie desperately attempts to keep her and Jacob's love life a secret, but when a patient with advanced Motor Neurone Disease is admitted her anger towards an instinctive Jacob builds, before she eventually exposes to the department they slept together. Dixie meets up with Jess as she attempts to get to the bottom of Olivia's injuries, but things don't quite go to plan.
Cal and Charlie visit Cal's biological mother - but another devastating bombshell is dropped on Cal as he learns his mother has Huntington's Disease and he has a fifty percent chance of inheriting it. Dixie learns Jess has complained about her unprofessional actions, but Dixie sticks to her instincts and promises to get to the bottom of what is really going on with Olivia.