Connie's old boss Andrea returns to the ED the same time her young heart patient is admitted, but Connie's concerns are soon raised when Andrea becomes insistent on operating. Ash decides to cover for Rita, while Lofty treats a distressed young male.
Connie decides to take a select number of her staff out on a day following the hospital's recent success, but when Ethan takes his eyes off the road for a second too long the team are embroiled in a horrific road traffic collision - with devastating consequences for one character.
A few old faces gather as an emotional day arrives for the staff. Ethan leaves his bed to attend the funeral, while Dixie distracts herself. Iain returns, while a new Tea Lady, Honey, catches the eyes of Noel.
Connie is left questioning herself when a man dies mysteriously in the ED. Dixie can't help but blame Ash for Jeff's death. Cal works closely with Ethan and Charlie on a virus which connects two patients.
Rita and the staff struggle to deal with a football riot which overspills from a pub to the ED. But things soon turn dangerous as a flare is set off, resulting in a man's face being severely burned. Rita is promoted to senior staff nurse.
Ash is angered by an asylum seeker who refuses life-saving treatment because she's a Jehovah's Witness. Big Mac experiences his first day as a Health care Assistant. Ethan pairs up with Dylan to treat a teenage girl fearing ovarian cancer.
Ash and Dylan disagree on how to treat a suspected 19-year-old overdose. Cal flirts with Zoe's patient, irritating her. The paramedics receive a hamper basket addressed to Jeff, but the contents is rather peculiar when it turns out to be a turkey.
Connie continues to struggle looking after Grace, and lashes out at a patient who can't feed her family, forcing Charlie to step in. Noel begins to accept Honey as his daughter, but remains frightened at the thought of being a father.
Connie treats a feisty female who demands instant treatment, resulting in her growing further and further apart from Grace. An elderly man falls through a shed roof in an attempt to leave after a one night stand, but Zoe reveals he has scurvy.
Connie throws herself into work after losing Grace. She treats a family of three after their car crashes into scaffolding, but the father shows interest in the daughter only. Big Mac steals from the food bank.
Rita fights for a female soldier after an explosion during training leaves the Corporal questioning the true events - with false answers being thrown about. It's inspection day at the ED - what could go wrong?
Dixie and Iain put themselves in danger when a caravan hangs over the edge of a cliff. An elderly male with Motor Neurone Disease uses his carer to attempt to kill himself, so Connie puts him in his place.
Amy Hills, an air hostess, is crushed under hand luggage, knocking her unconscious. When she arrives at the ED, her relationship with her husband strains. Connie continues to personally blame Rita for Grace's departure. Iain receives a verbal warning.
Lily falls asleep whilst driving home on her moped, causing her to collide with a school girl.A man is admitted after a meth lab explosion. Rita and Connie's feud comes to a head, with Rita getting her staff to abide by their role, instead of doing extra jobs for the doctors.
Zoe faces every doctors most difficult decision: treating a six year-old who has been run over by her father, or saving a pregnant mother from an RTC. Initially prioritising the young girl, she dies. When the pregnant lady arrives, her and her daughter die. Zoe then reflects and wonders what she would have done differently. Then, she retakes her day, this time prioritising the six year-old. She dies, but the pregnant woman's daughter survives. However, Zoe then reawakens and realises she's up half an hour early - she manages to save the six year old and the pregnant ...
Connie's friend Alfred goes joyriding with a mate who previously had MND, however when they crash their car on a roundabout into a young girl she saves Alfred's friend's life. Later in the ED she makes up ongoing symptoms in order to make a claim on her insurance policy, but dies. A distraught Alfred becomes fully paralysed and asks Connie to assist him in dying, but will she help him?
Connie is horrified when Alfred asks her to help him die. A pregnant young lady gives birth in the back of the ambulance, but Connie is concerned the young girl was coerced into agreement when her teacher storms in claiming it to be her baby. Ethan and Cal treat a bully and a victim when the victim tweaks a science experiment - causing an explosion in the lab.
Connie is distraught as Alfred passes away in the ED. Rita becomes suspicious over her actions and asks for a toxicology screening on Alfred. A construction worker suffers a mysterious illness and his digger loses control - causing it to knock his daughter into a hole and cover her in bricks, before knocking the digger hand into the ED.
Connie is questioned over the murder of Alfred Maxwell, but things take a nasty turn as Connie tells the police to investigate her office, which she claims has the medication she gave to Alfred. Just minutes before the police arrive Rita snatches the medication - leading to Connie being charged for murder. Lofty and Robyn argue as he kisses another patient.
Connie is suspended following the arrest, and is not granted bail. Charlie and Rita continue to fight over the medication which potentially could set Connie free - struggling with a guilty conscience she hands them over, setting Connie free. A young girl slashes her wrists and is admitted, but reveals she's in a sexual relationship underage and with a man in his thirties. An elderly female with dementia is admitted. Charlie gets a call from Louie's girlfriend - he's been beaten up and needs urgent help.
Cal and Ethan help a young adult come to terms with his adoptive mother's terminal cancer. Connie makes an abrupt returns and takes over Dylan as Clinical Lead again. Zoe helps a young boy speak up after being involved in a car crash.
Zoe and Dylan get to the bottom of a botched team-building exercise when a girl's leg is caught in an animal trap and two friends are entangled in barb wire. Louie is attacked by junkies, causing his heroin addiction to become well-known by the staff.
Dixie treats a woman who crashed her car, but when she reveals her son was also in the car, Dixie fears the child has been abducted. Dixie later finds herself on the edge of Holby Pier talking to Suzy, the child abductor, out of jumping with the kid.
Cal makes a surprising discovery after a beauty pageant is involved in a car crash, but later convinces the pushy mother to come clean about her deception. Dixie and Iain race time to save a man from dying as a result of his dodgy boiler in his house.
Jacob Masters, a nurse, bursts into the ED with a girl over his shoulder. She's been rendered unconscious by some unknown alcoholic substance. Jacob later realises that she's suffering methanol poisoning. Cal struggles with the work involved in becoming a consultant.