Beetlejuice is the host of a Neitherworld TV show featuring famous historical dead people as guests, but he has to contend with constantly fluctuating ratings and The Monster From Across The Street who's not happy that his favorite show has been bumped off the air to make room for Beetlejuice's.
Fitness freak Jacques LaLean enters the Mr. Neitherword Bodybuilding Bontest (with Beetlejuice as his manager), but there are problems: first, Jacques is a skeleton and has no body to build up and second, the current titleholder (who's held it for 399 years) isn't above cheating to keep his title.
A snooty nouveau-rich husband and wife move next door to BJ's Roadhouse and, finding their new neighbors too poor and common, buy the Roadhouse and have them evicted. To get even, Beetlejuice gets a Monster Credit Card and a buying war ensues. But will Beetlejuice be able to eventually pay for all the things he's bought?
Even when playing golf, Claire Brewster is her usual obnoxious self, so Beetlejuice takes her and her opponent (Lydia) to the Neitherworld to play golf, but once there Claire becomes the trophy in the Neitherworld golf tournament.
Despite feeling extraordinarily self-conscious about her appearance, Lydia is kidnapped by a beast from the Neitherworld named "Thing Thong" who collects beautiful things because he thinks he's ugly. While being held hostage, Lydia decides to help give him self-confidence, while Beetlejuice tries to track Lydia down by disguising himself as famed explorer Grimdiana Bones.
Edgar Allen Poe stays at B.J.'s Road House, and agonizes over his lost Lenore so much that it irritates him, but since he keeps throwing money around in his direction, he tries to tolerate Poe's depression as best as he can.
During a physical examination, Beetlejuice's skeleton become separated from his body, adopts a very snooty personality and goes off on his own, but unless Lydia can get them back together "Beetlebones" is likely to get picked up by The Bone Patrol!
Since the winner of the Neitherworld Beauty Pageant will win a ton of money, naturally Beetlejuice tries to enter, but the contest is only open to women. Also naturally, this isn't going to stop him, so he leads a protest to allow men (and other things) to enter, and once in he'll do anything to make sure he wins.
When the Happy Girls' outdoor excursion is rained out, Beetlejuice takes Lydia, Delia, Bertha and Prudence to a Neitherworld amusement park themed around Bartholomew Bat, an old Neitherworld cartoon character. But the black-and-white character has dark and sinister plans in hand, and soon Lydia is the only one left to stop him...
In a spoof of "Brigadoon", Beetlejuice, Lydia and a damaged Doomie crash-land in a mysterious village that only appears once an eternity, and if they don't escape before all of the (Scottish-accented) village inhabitants fall asleep, they'll be trapped there forever!
When a jealous Claire deliberately humiliates a female foreign exchange student, Lydia, Beetlejuice and the rest of the Neitherworld gang decide to teach Claire a lesson by making her a foreign exchange student to "Scrungylvania".
Beetlejuice's parents have a chance to join the Neitherworld's Society of Oldest and Moldiest Families, but to prove their pedigree have to produce their family's (literal!) Coat of Arms, which is somewhere in Beetlejuice's possession. When cleaning Beetlejuice's room to find the Coat of Arms proves unsuccessful, Beetlejuice and Lydia must travel to the World of Lost Items and find it.
Poor nervous Charles is badly in need of rest and relaxation, so "Mr. Beetleman" books the Deetz family into the Hotel Hello resort in the Neitherworld. However, once there, the oblivious Delia becomes the unknowing target of a vampire count.
Friendly Neighbor Day in the Neitherworld is not going too well in Beetlejuice's neighborhood (thanks naturally to Beetlejuice), so good fairy Goody Two-Shoes is sent to make sure that everybody is nice to each other. However, it turns out that she is determined to make everybody toe HER line, and Beetlejuice must organize the neighborhood to stop her before her "goody two-shoes-ness" destroys them all.
"The Ghost with the Most", while trying to get some sleep, finds himself haunted by the most persistent, obnoxious and dangerous of all spirits...a poultrygeist! Nothing he can do will drive or keep the "fowl" pest away, so finally in desperation he turns to Lydia for help, but can even she do anything?
Beetlejuice gets depressed one day when none of his friends fall for his pranks. Believing that they'd be better off without him, Beetlejuice wishes that none of his friends had ever met him. After a strange man grants his wish and Beetlejuice sees how different things are without him, will he realize what an important role he plays in the lives of his friends?
Jealous over a Neitherworld "tell-all" author's success, Beetlejuice decides to write his own tell-all autobiography. The problem is, while it makes him a huge success, nothing in the book about his friends is true and Lydia isn't even mentioned!
Lydia has developed measles, so Beetlejuice takes her to the Neitherworld to cure her with Neitherworld home remedies. However, while she is actually cured, Beetlejuice contracts Cabin Fever and both he and Lydia are quarantined! Now Lydia must find a way to cure Beetlejuice before the Cabin Fever drives him totally bonkers.
While cleaning Beetlejuice's room, Lydia finds Beetlejuice's high school yearbook with a picture of him as Homecoming King and asks him to tell her all about it. The trouble is, the story he tells her isn't exactly the way it actually happened...
When a highway project (okayed by a corrupt Mayor Maynot) threatens to destroy the roadhouse, Beetlejuice is persuaded to run for mayor against Maynot...and actually wins! However, once in office he falls victim to the same corruption and begins taking huge bribes. Now it's up to Lydia and the rest of the gang (who helped get him elected) to get Beetlejuice thrown OUT of office!
Lydia can't seem to understand Shakespeare's work, so Beetlejuice takes her to the Neitherworld to meet Shakespeare's characters, who capture Lydia and demand that she write new plays for them to act in.
Beetlejuice is chosen to replace a film star in a major Neitherworld horror film, but the ensuing fame turns him into a total jerk. Lydia (and the director not letting him do what he does best) brings him to his senses, but he is trapped by his contract, so Lydia comes up with a plan to get him thrown off the film and replaced by the former star.
Beetlejuice's brother Donnie (whom everybody loves but Beetlejuice can't stand) comes for a visit, and his popularity among Beetlejuice's friends (and with Lydia) sends Beetlejuice into major depression.
During a major Prankster competition, Beetlejuice is framed for Shop-lifting (literally!) by his opponent and sentenced to rehabilitation in Never-Never-Land, a place of saccharine sweetness where they are determined to break Beetlejuice's spirit...and actually succeed! Lydia finds out what has happened, but when she and "Snugglejuice" are brought back to Never-Never-Land, the beings in charge subject her to the same fiendish brainwashing treatment!
Beetlejuice (who can't stand healthy food) adds some Gore-egano to Lydia's Caesar salad, bringing it to life and determined to conquer the Neitherworld! Now Beetlejuice and Lydia must travel to A-Roma, a land of living vegetables, to stop veggie dictator Caesar Salad's evil plans.
To counter the normal dullness of Lydia's school day, visiting "Professor Beetleberg" brings Lydia, Bertha, Prudence and Claire to the Neitherworld to visit History Land, an interactive museum of the Neitherworld's version of historical (and sometimes hysterical) events.
The Monster and Monstress Across The Street have a major quarrel and split up. Now The Monster is miserable, and he's making his neighbors miserable as well! Beetlejuice must get the Monster and Monstress back together somehow, so he comes up with a plan to make the Monstress jealous...but it doesn't quite work out as planned.
In a spoof of both "The Wizard of Oz" and "Shane", Beetlejuice, Lydia and Doomie travel to the Neitherworld's Mid-West to take over a dairy farm owned by Beetlejuice's Aunt Emma. Once there, Beetlejuice must contend with a Big Enchillada (literally!) who is determined to take over the whole territory, while Lydia is forced to become the town's new "School-marm". Beetlejuice is for taking the easy way out (taking the Enchillada's money and running), but Lydia (and Doomie) are ready to join the townspeople in fighting the bad guys.
Lydia decides to direct her own episode of "Disasterpiece Theater," with Beetlejuice in the starring role of Captain Ahab in Moby Dick. But all may not go so well, when the haughty whale refuses to work with B.J., who lets his part go to his head and vows to rewrite the play his own way.
After being hit on the head by a falling satellite, Beetlejuice has (naturally!) somehow lost his memory, so he, Lydia and a Neitherworld psychiatrist must travel into Beetlejuice's body to his brain to try and unlock his memories. However, the journey through Beetlejuice's body in a miniaturized submarine won't be as easy as hoped for...
Beetlejuice is framed by Scuzzo the Clown for Joke-stealing, sentenced and sent "up the river" to prison. While Lydia tries on the outside to uncover the truth and get Beetlejuice freed, Beetlejuice must deal with a prison run by a most unusual warden, and his repeated escape attempts aren't exactly endearing him to the warden...
Lydia has hurt her foot but is scared of hospitals, so Beetlejuice takes her to Seizure's Palace, a Neitherworld hospital which seems more like a five-star Las Vegas hotel. However, when the hospital's planned Pay-per-View gets into trouble, the administrator plans to broadcast a substitute Main Event: A Total Body Transplant...with Lydia as the patient and Beetlejuice as the operating doctor!
After a slight dip in the ratings, Mr. Monitor threatens to cancel Beetlejuice' show. BJ's negotiation attempt backfires and he gets fires, leaving Lydia to do a watered down version of their on her own. He then has to work his way up from the mail room. But soon his star is rising once more after stealing a co-workers new ideas for TV shows.
A female character in a Neitherworld B/W SF series has rebelled and taken over, and the show's Rod Serling-like writer/host turns to Beetlejuice for help. Can even The Ghost With the Most stop her or will Lydia save the show?
Beetlejuice's latest scam - phony Neitherworld driver's licenses. He is caught and sentenced to the Neitherworld Traffic School, but the "Dragnet"-type detectives after him are more interested in donuts than law enforcement.
When a Neitherworld forest containing the most delicious beetles is threatened by Prince Don John and the Sheriff of Rotting-Ham, Lydia convinces Beetlejuice to become "Robbin'" Hood - but "outlaw" isn't so selfless.
Beetlejuice's brother Donny has become an ecological terrorist (planting trees all over the Neitherworld), and when Mayor Maynot puts a bounty on Donny's head both Beetlejuice and a famous Neitherworld bounty hunter are in a race to get it!