Spike Lee was kicked off the campuses of Morehouse, Spelman, and Clark Atlanta University during filming because the colleges' Boards of Directors had concerns on how black colleges were being portrayed in the film. Lee had to finish filming at the neighboring Morris Brown College.
Spike Lee had the actors stay in separate hotels during filming. The actors playing the "wannabes" had better accommodation than the ones playing the "jigaboos", which contributed to the on-camera animosity between the two camps.
'Vanessa Williams' was originally considered for the role of Jane Toussaint. However, Spike Lee was impressed by 'Tisha Campbell''s singing performance in Little Shop of Horrors (1986) that she got the part.
The matching kneepads that Kyme and 'Tisha Campbell' are wearing in the Straight and Nappy scene were not part of the wardrobe. Tisha Campbell had a knee injury throughout the shoot and the stylist gave Kyme a kneepad to match.