Thom Mathews and 'James Karen (I)' nearly duplicate their roles from Return of the Living Dead as a pair who are sickened by zombie gas. In both films they have the exchange, "Listen kid, if you like this job..." "Like this job? Like this job!"
The music score on the DVD release is almost completely different to the original theater, laserdisc and VHS versions. This is widely said to be because of difficulties obtaining the rights to use the original score. However, the original score can be heard on the French audio track.
Writer/Director Ken Wiederhorn was trying to get out of the horror genre at the time Lorimar Productions bought his script. Once the film was released he received nothing but horror-comedy directing opportunities.
The cemetery and storm drain were complete outdoor sets. The mausoleum, hospital, meat packing factory, and interior houses were also purpose-built sets.
The dialog from the operator on the Special Army Emergencies telephone line is word for word exactly the same as in The Return of the Living Dead, complete with "Hold the line Mr Wilson, you are being transferred", thereby tying this films hero, Jesse, with Burt Wilson (Clu Gulager) of the earlier film.
The script was not originally written as a sequel in the "Living Dead" franchise. Producer Tom Fox was interested in Wiederhorn's story, but would only finance it if he agreed to make it a part of the series.
At the end of the original VHS tape, there is a commercial for a number that you can call to order clothing from the movie. This was a limited time offer from the company Movie Tees. You could order a white tank top, a black or white t-shirt, and a black and white sweatshirt with 3-4 different designs.
'Brian Peck' is the only person to have a role in the first 3 movies in the 'Return of the Living Dead' franchise. Playing the role of 'Scuz' in the first, many of the closeup zombies in the second ('Pussface', ''Thriller', 'Jaw', 'Eye-Pop', 'Zombie on Car Roof') and finally 'Ballistics Technician' in the third.
The issue of "Peter Parker: The Spectacular Spider-Man" that Jesse takes out of his comic-book box at the beginning of the movie is number 53, from April 1981.
Despite having directed several horror pictures, director Ken Wiederhorn was not a fan of the horror genre. Many cast and crew members expressed in interviews that they were displeased with his lack of enthusiasm towards the project.