Dr. Alien (1989)
Wesley: You stay away from me. You are not of this earth!
Xenobia: Wesley, you say that as if it were a negative thing.
[after the sexually violated Wesley won't come by free will to the aliens' home planet to impregnate the female aliens there]
Xenobia: Please, think about the fate of our planet!
Wesley: Oh, sure, just like you thought of what this stuff would do to me. You tampered with my life. You violated the "prime directive"!
Wesley: Didn't you guys ever see Star Trek?
Drax: Well, I liked the first two seasons of the old show, and a couple of the movies were okay, but...
Xenobia: What is this "prime directive"?
Wesley: Ah, it's a rule they had about not interfering with people and cultures on other planets... like you did.