Jack Killian retires from the San Francisco Police Department after accidentally shooting his partner, Rusty, in a crossfire situation. He's drawn back to the world of the living by an offer to be a late night talk radio host. A serial killer begins calling Jack, explaining the assassinations and Jack's inadvertently pulled back into the crime fighting world.
Jack spends most of his radio show talking with a homicidal/suicidal 'spurned lover' - the man is waiting to kill his girlfriend and then himself. It's a race against time for the police to track down the location of the woman's home.
Jack's old girlfriend, Tina, arrives in town. She informs him she has contracted AIDS and will die. Unable to handle the hopelessness of the situation, Jack sets out to find the man responsible. Jack is shocked to see that the message of safe sex is still being ignored, despite the obvious consequences. He uses his show as a forum on AIDS awareness as well as a means of tracking down the man who infected Tina.
A female friend of Jack's from the police force is wounded in the line of duty and her partner killed. They seek comfort in each other's arms to grieve the deaths of their partners. Jack finds himself in the crossfire of the mob hit man trying to silence the only witness to the crime.