When Danny Tanner's wife Pamela is killed in an auto accident, he finds himself left all alone to raise his three daughters: D.J., Stephanie, and baby Michelle. Fortunately Danny's hair-obsessed, rock-star brother in-law Jesse Cochran, along with Danny's flamboyant, cartoon loving friend Joey Gladstone, move in to help Danny raise his girls. On the first day, D.J. runs away, and Jesse and Joey find extreme difficulty and anxiety in changing Michelle.
While broadcasting a national fight, Danny lets some information about the fighter's home life slip out that could get him in a lot of trouble. Meanwhile, on the home front Joey and Jesse worry when Michelle develops a cough.
Joey fears that the family doesn't need him anymore when they give him a too-joyful send off. But in reality, they are planning a way to surprise him with space of his own. Meanwhile, Jesse learns that Joey's job as child care provider and housekeeper is not an easy one.