Frances Bavier, who originally played Aunt Bee in the series, was ailing and homebound when this movie was made. She considered recording a brief audio segment but decided against it. Another actress does that part, which is heard as Andy lays a flower on Aunt Bee's grave.
By 1986 the original outdoor set from The Andy Griffith Show (1960) had been destroyed, so the Mayberry town square had to be re-created in a small town in California. This results in the road that originally came to an end in front of the courthouse now going straight on by, being much wider, and a flagpole being in the middle of the street.
Return To Mayberry was only the third time in the show's (and spin-off show's) history that Gomer and Goober appeared on camera together. The other 2 times were The Andy Griffith Show in "The Fun Girls" and Gomer Pyle U.S.M.C. in "A Visit From Cousin Goober".