In 1997, two years after the end of the series, Andy Griffith reprised the role of Matlock on a two part episode of Diagnosis Murder (1993). This would mark his final appearance in the role, and the only time the Matlock character was seen on CBS. In the episode, it is explained that Dr. Mark Sloan, played by Dick Van Dyke, advised Ben in 1969 to invest his life savings, $5000, in the 8-Track Tape industry. When Ben lost all his money, he began buying cheap suits off the rack and eating hot dogs because they were all he could afford. By the time he had money again, it was a habit.
Clarence Gilyard Jr. appeared in almost every episode of the NBC edition of the show, after he joined the cast, before production moved to North Carolina for the series seventh year. He was about to co-star in Walker, Texas Ranger (1993), which made Gilyard's scheduling more difficult.
During the third season of Matlock (1986), Kene Holiday had missed a total of 7 episodes, because he was sent to a rehabilitation clinic for his drug and alcohol abuse, where he stayed on an outpatient basis. By the time he became 3 months sober, he was already fired from the show.
Clarence Gilyard Jr. and Daniel Roebuck were series regulars together for all of season 7 and a few episodes of season 8 (when Gilyard left), but due to one or both not making an appearance in a given episode, they were only in two together.
Clarence Gilyard Jr. and Daniel Roebuck, who played Matlock's private investigators, also appeared in movies featuring Paul Gleason as an officer of the L.A.P.D. Gilyard appeared in "Die Hard" (1988), and Roebuck appeared in "Money Talks" (1997).
Billy Zane and Frances Fisher both appeared on "Matlock" years before their respective roles as the fiancé and mother of Rose (Kate Winslet/Gloria Stuart), the main character of the 1997 blockbuster "Titanic."