The studio, expecting the film to perform poorly at the box office, pushed for a relatively quick release onto home video; however, the film was one of the 'sleeper' hits of the season, thanks to terrific reviews and positive word of mouth, and had a lengthy stay in theatres, and was still in theatres, in fact, when it was released to video stores.
John Huston is the only director to direct two members of his own family to win Academy Awards. The first was his father Walter Huston in Treasure of the Sierra Madre who won best supporting actor, then his daughter Angelica Huston won best supporting actress for this film.
The voice that is heard saying "Maerose" off camera when Anjelica Huston is putting makeup on her face in the scene when she tries to kill her father (in the movie played by Lee Richardson) is actually voiced by director John Huston, who was Anjelica Huston's real life father.
This is the first film on which Lawrence Tierney has worked with a cinematographer called Andrzej. He's Andrzej Bartkowiak; later Tierney worked with a cinematographer called Andrzej Sekula on Reservoir Dogs (1992). Incidentally Tierney's co-star Jack Nicholson in Prizzi's Honor (1985), previously worked with Bartkowiak on Terms of Endearment (1983).
Director John Huston and writer Richard Condon - who wrote the novel on which Prizzi's Honor (1985) is based, plus he co-wrote the screenplay - both have surnames that end with the letters "o-n", plus both surnames have six letters each.