Drs. Hayes and Lincoln are researchers in biological oddities for the Humanidyne company. When they find a man still alive after being frozen for 50 years, their greedy boss fires them and takes the Iceman to use for military experiments. Left without jobs, Hayes and Lincoln decide to get a group of "freaks" (including a telekinetic 17-year-old and a rock guitarist who shoots lightning from his hands) together to rescue the Iceman and stop their boss' reckless experiments.
A man, who has never left his homeland, miraculously travels from one side of the ocean to the next on a wooden raft to reach the Space Shuttle in time. The Misfits desperately try to help, but he keeps wondering off from them.
Johnny is fascinated by a woman he's met, Gina. But whenever he meets her she disappears when he's not looking. At the same time some of the misfits believe to have seen a monster in the sewer system, so all of them go down again to investigate. They discover a young boy who's become unconscious due to supposedly bad air. Also at the same time a party is being planned for the opening of an exhibition of valuable relics from the Titanic at the museum. It turns out that Gina is working together with a group of criminals, who were planning on placing a bomb in the sewer ...
A meteor impacts on a farm and radiates the cows grazing there. All is well until they are converted into hamburgers and served, unknowingly, by Gloria to three Senior Citizens who develop powers. Shortly thereafter, problems arise.
Billy is reunited with an old friend from high school who, through Humanydine, enlists the help of the Misfits in his Top Secret mission. As the mission unfolds as do the secrets and dangers of Billy's friend.
The Misfits agree to help a former German spy reunite with his daughter who he was separated from 25 years ago in Germany. To do it, they use their powers to stage a magic show for the athletes she came from the Soviet Union with.
Gloria's pen-pal Jaye, having stolen a bracelet, is the object of some unidentified assailants. In the following pursuit Gloria gets kidnapped instead, Billy and El get arrested, and Jaye manages to escape with Johnny.
When Billy attempts to break the world record for staying awake, he begins to have hallucinations concerning his past adventures. He finds himself in an alternate reality where all his friends have different personalities and different jobs.