MacGyver is kidnapped by enemy agents to retrieve sensitive information he stole from them. To get him to talk, they inject MacGyver with a hallucinogenic drug that will kill him in six hours, unless an antidote they have is administered.
A cruise ship is the target of a terrorist attack and has three bombs hidden aboard. MacGyver and a friend from the agency are asked to dismantle the bombs before it's too late for the crew and passengers.
In Bulgaria, MacGyver collects a top-secret microfilm and attempts to smuggle it out of the country. At the airport he meets a mysterious beautiful American girl, who turns out to have ties to the Bulgarian Secret Police.
While on a rescue mission in Soviet Afghanistan, MacGyver is shot and wounded. An Afghan woman and her son risk their lives to give refuge to MacGyver. A wounded MacGyver must now outwit the Russian Army to complete his mission.