Dorothy, Rose, and Blanche are three women who share a house in Miami, Florida. Dorothy's elderly mother, Sophia, unexpectedly moves in after her retirement home burns down, and Blanche accepts a proposal of marriage.
Blanche's sister, Virginia, with whom she has had a tense relationship for years, comes to visit. She reveals that she needs a kidney transplant to save her life.
Blanche dates an aerobics instructor who is considerably younger than she is. Meanwhile, Rose's mother comes to visit and resents the way her daughter treats her.
After Rose's boyfriend Al dies of a heart attack in her bed, Rose fears that she is a death jinx in the bedroom because her beloved husband Charlie died of a heart attack in her bed as well. To make matters worse, after Rose tracks down Al's sister to notify her of his death, she comes to find that his "sister" is really in fact his wife!
Blanche's father, "Big Daddy" Hollingsworth, visits with the news that he's sold his house and wants to become a singer. Meanwhile, a boundary dispute over a fallen tree leads Sophia to put a curse on the rude neighbor who refuses to move it.
The girls remember how they came to live together; Blanche put an ad for a room for rent on a grocery store bulletin board, and Rose and Dorothy answered it.