If Marla Gibbs was unavailable to star in 227 (1985), then, it would've debuted the season after 1985, if The Jeffersons (1975) would've been on the air. When the show was unexpectedly cancelled in 1985, Norman Lear allowed Gibbs to star in the show.
After gaining celebrity status, Jackée Harry, was at one point planning to leave the show to star in a pilot that has never been materialized, but left midway through the 1989-90 season, which was coincidentally, the final year.
A story line for the second season was considered in which Mary was to become pregnant, and miscarry the child at birth. Marla Gibbs said the idea was scrapped as the outcome would have been too much of a downer for a sitcom.
Co-creator/writer Michael G. Moye is credited under the pseudonym "C.J. Banks". Moye disagreed with the producers over the tone of the series and did not want his real name in the credits. "C.J." was the name of Moye's college theater professor.
Prior to the show's debut, NBC's promotional campaign included a TV spot narrated in a Rap style. This marked one of the earliest uses of Rap in a National TV Promo or Ad directed at mainstream viewers.