Crockett and Tubbs are investigating the murders of prostitutes which appears to be the work of a sadist. They discover that the killer is a Chilean police official. They try to arrest him but someone from the government gets him out. It's obvious that the government man and the Chilean have something going on. So they try to find out what it is.
Castillo goes under cover as a drug lord to break up another operation, but things are complicated by a group of paramilitary Indian tribe members who want to stop the ring and restore honor to their tribe which has been caught up by ring leader's greed. To further complicate matters, the tribe and the drug lord are about to cross war paths.
While under cover to bust a drug lord, Crockett and Tubbs are caught in the middle of a DEA agent and the director of homicide wanting to bust a sudden show of 100% pure cocaine being found injected into the dead bodies of kidnapped teenage girls, and the drug lord enraged over the killings which are drawing unwanted attention from the police. Things go from bad to life-threatening worse when a shocking twist puts Crockett in an awkward situation.
When a convicted rapist is released after serving just 20 months, Trudy tries to protect the victim from further torment. The entire OCB team end up getting involved, some protecting the victim and some protecting the rapist after she hires a mercenary to kill him. Needless to say Castillo is not happy about his team going outside the law.
A drug kingpin on trial for murder puts a million dollar contract out on a punk rocker who is the star witness for the prosecution. The FBI want Crockett and Tubbs to safe house the witness, but keeping him alive is going to be a challenge.