Jonathan and Mark become counselors at Camp Good Times, a summer camp for children with cancer, to help two cancer patients: a frightened little boy with an overprotective mother and an angry teenage athlete who may lose his leg to bone cancer.
Camp Good Times is helping both Gary and Curtis in different ways, but Jason may have lost his will to keep going when his best friend is rushed to the hospital and his father still refuses to deal with Jason's illness.
When Mark wishes that Jonathan be a mortal cop "for just a little while", "The Boss" takes him up on his wish with the result that Jonathan must relinquish his angelic powers...which, considering the dangers of being a police officer, may not be a good idea.
A modern-day Hollywood retelling of the Cinderella story, only this aspiring actress Cindy wants to be accepted for who she really is and not the Eliza Doolittle her well-meaning dad wants to transform her into.
Out of fear of losing their jobs, workers at a factory ignore ground-water contamination (even though the contamination is making their children sick), and Jonathan must resort to drastic measures to force them to face the facts - but the consequences may be just as fatal to him.
Mark is the only one who can help when his friend's fifteen-year-old adopted daughter tries to find her biological mother and the unexpected uncovered truth threatens to tear the family apart completely.
The two-part episode "The Monster" concerns the intertwining plot lines of Julian Bradley, a young artist with a facial deformity treated as a local "boogeyman" by the townsfolk, and Jonathan and Mark's quadriplegic friend Scotty, now an attorney whose practice is failing (since nobody wants to hire a quadriplegic attorney) and whose marriage is also in danger of failing. When Julian meets Rachel, a blind girl, they fall in love, but an operation that may restore Rachel's sight may also destroy Julian's hopes.
Jonathan and Mark go to work at a football team. And one of the players whose worried about getting cut asks for drugs from the team doctor Dan Hickey, gives it to him. And also Hickey is very hard on his son who's a medical student and helps his father, his son takes drugs to cope. And Hickey is also taking drugs.
A homeless boy wishes that someone would love him and so Jonathan comes to him and offers to make his wish come true. They go to a man whose separated from his wife who refuses to let her see their son. And he also refuses to believe that his son who's confined to a wheelchair is because of something psychological.
Jonathan and Mark emerge from a meteor crater to offer extraterrestrial encouragement to Adam, a young, bullied orphan whose eccentric grandfather is in danger of losing him to a heartless social worker.
While working for Linda Blackwell, a beautiful movie star with a very low opinion of men, Mark and Linda both wish "to God" that each could have the other's life ... with the result that "The Boss" takes them at their word and switches Mark and Linda into each other's bodies.
Jonathan and Mark help a whole town to remember how a young soldier who was killed in Vietnam touched their lives when the attempts of his father to have a memorial made to commemorate his son are ignored.
Mark becomes deeply stricken with grief after believing he caused two tragedies involving young girls - one of them a victim of a car accident, the other trapped in a house fire - in a matter of hours. That, along with a litany of other complaints, prompts Mark to make a demand: That Jonathan erase everything that's happened and allow him to create his own vision of "Heaven on Earth."
Mark and Jonathan try to reunite a mother with her son who is now the Deputy Premier of the U.S.S.R. When he is told that his mom would like to see him he believes Jonathan is with the CIA and not an angel.
A home for unwed mothers is endangered when a sensationalist reporter uncovers a secret about the past of the woman who runs the home, and a teenage boy must come to terms with the fact that he's a father.
Jonathan and Mark are substitute teachers in a high school where a lesson on true friendship is underscored by Jonathan's assigning an ostracized overweight girl to tutor a brash baseball star in danger of flunking out of school.