Whenever the script called for an animal transition, the production designer, director, set decorator, stunt supervisor, animal wrangler, and actor had to carefully coordinate every move. Shooting on a soundstage allowed more animal control; location shoots were very difficult. When one script required a cobra, the entire set's perimeter floor and walls had to be sealed to prevent the cobra from escaping. A low wall was placed at the open end of the set to seal the stage. To set up filming action scenes with the snake, the camera crew had to lift their equipment into walled-off stage area. The snake wrangler supervised the animal's movements.
Creator Glen A. Larson briefly resurrected the Jonathan Chase character for a crossover with his series NightMan (1997). Manimal's traditional practical-effects transformation was abandoned in favor of a CGI sequence.