When a boxer goes out to dinner with his wife, doctor and promoter. The doctor's nurse who arrives wanted to talk to the boxer but before she could she gets killed. His wife goes to Houston telling him that she thinks someone might be trying to kill her husband because he's had a few close calls lately. But the boxer doesn't want Houston around.
Cat food magnate Felix Randolph is killed by his pet tiger. The grounds-keeper is arrested but Houston thinks the killer is one of four ex-wives, who accuse each other and cannot lay claim to the estate until the murder is solved.
While being named Commodore of a yacht club, boorish Rawson Harmon IV is killed by a snake. Manager Honey Lewis asks Houston to investigate. Suspects include Honey; her restless son Jeb; sleazy filmmaker Bevak; & gambler Binky.
Houston goes to the office to meet some people who asked to see him. But when he gets there, he learns that they think he asked them to come. But Houston doesn't know all of them. But then one of the guests says that they do have something in common but that's when he's killed. And they find themselves locked in. And that's when someone is sending them messages which are suppose to be hints of why he is targeting them. And more people are getting killed. And more messages are being sent.
When a man Houston sent to prison escapes, he then makes an attempt on Houston but gets Bo instead. Houston tries to flush him by shaking down his old associates. He then learns that the man was broken out by a deranged billionaire who became a serial killer whom he caught, who's been in an insane asylum, so he has to find out how he's doing it. He also finds out that the man has recruited a couple of other men to get Houston.
Womanizing scientist Ivar Mardosian dies of an induced heart attack while in the desert with colleagues awaiting alien contact. Are aliens really visiting, or is this a staged hoax to cover up a murder? And who killed him?
Two men dressed like Laurel & Hardy try to kill C.J. Houston learns that some of her former sorority sisters have already been victims, and that the man that they had been dating could be responsible. But others are marked for murder, too.
During a carnival fund-raiser, vicious gossip columnist Vonda Moran is blown up because someone tampered with a "strength test" mallet & ringing bell attraction. Houston is subsequently kidnapped and persuaded to investigate.
Bloodied gunfire victim Eric Brant lands in a passing car, hands the driver a codebook, and gives her a message for Houston: Fear for Tomorrow. Brant dies when the car blows up. His assailants then go after Houston's buddy Vince Novelli.
After Houston's friend Winston Fowler's top jockey Cindy Gaines breaches her contract with him to move to England, she is fatally pitch-forked in a stable. Houston is found standing over her remains and subsequently arrested for her murder.
At a mystery writers' convention where Houston is the keynote speaker, publisher Wayne Slocum shoots hated mystery writer Emily Armor three times with a .45 magnum, then brazenly entreats his friend Houston to help solve her murder.