Michael Knight and K.I.T.T. come to the aid of some fashion designers after two of their ilk are murdered by a custom car. When Knight gets hurt by the car in question, he starts to take the case personal.
An acquaintance from a previous case, Maxine Flemming, loses her race horse King Jack after an accident. However, Michael soon surmises that the horse hasn't been shot as Maxine was led to believe, but being put is up for sale by her partner Tommy Lee to pay of his gambling debts.
While on the trail of toxic polluter "Acid" John Birock, K.I.T.T. ends up in a pit filled with acid and is all but destroyed. The car has to be rebuild from scratch by the original design team consisting of Dr. Von Voorman, Dr Breland and Dr. Numata. But once reassembled, the world's most sophisticated car seems to have lost it's nerves.
Bonnie asks Michael to look into the apparent suicide of her idol, Harley Freeman. Michael disguises himself as computer scientist Dr. Knightwood and parachutes into 'the Retreat', a private rest and relaxation compound filled with beautiful women. K.I.T.T. has to stay out of sight and finds himself coping with Sheeba, the lion cub the women's keep as a pet.
A truckload of confiscated weapons including 2 laser rifles are stolen from a police warehouse. Michael finds a female hitchhiker selling part of the shipment at a Survivalist convention held at a hotel.
The Foundation has accidentally developed a powerful new isotope, Cernium 116. Jennifer Knight, Wilton's daughter takes this opportunity to cut down on FLAG expenses. Rebuild terrorist Phillip Nordstrom kidnaps Devon and replaces him with a duplicate in order to extract the secret of K.I.T.T.'s Molecular Bonded Shell. Having found a way to neutralize it, Nordstrom unleashes his own super vehicle, the Juggernaut on an unsuspecting K.I.T.T. Without any resources to fall back on, Bonnie enlists the help from Chicaco crime fighter the Street Avenger (aka RC3) to help ...
Jeff Cavanaugh, another crook arrested by Michael in a previous but unseen adventure, escapes from jail with help Julian Martin. Fearing FLAG is on his tail, Julian decides to kidnap Mike's latest flame Karen and also gets his hands on K.I.T.T.
On her way to her sister's wedding in Boston, Bonnie's plane is highjacked by the New Dawn Movement. Its leader, Charles Zurich, plans to trade his hostages for 197 prison inmates and forces the plane to land at a military base housing a project known as Deep Sleep.
An archaeologist being sponsored by FLAG is kidnapped after finding proof positive that a piece of land belongs to a tribe of Indians. Not surprisingly, a business man who wants to drill oil in the same area is the culprit.
A gang of bikers with a knack for high-jacking semi's gets hold of the FLAG mobile headquarters by accident. With the help of a young computer whiz they use the Foundation equipment to rob a bank, then set their sights on an experimental new vehicle called the Ferret.
The entire roster of FLAG personnel goes undercover to stop an American diplomat from selling a biological weapon to 'The Hammer of the Desert'. K.I.T.T. is disguised as a '55 Lynx Imperial racing car they plan to offer for sale. RC3 poses as the middle man, Bonnie as the seller, 'Alicia Craven-Hall'. Michael pretends to be hired killer Johnny Hajeck and even Devon joins in, playing the part of a newsreader.
Although Devon would rather have Michael on a Rembrandt forgery case in Cincinnati, he allows him to help a mechanic friend of Bonnie's, Elena Thomas, who's facing sabotage on the racetrack. Since Elena's top driver has been killed in an accident apparently caused by her faultiness, Michael volunteers to take the man's place.
FLAG architect Matt Erickson is the victim of a pickpocket at his own party that Bonnie & Michael are attending. The thieves turn out to be two female prisoners let out by their scheming warden to test their abilities for a big heist. After Michael and K.I.T.T. track down both suspects to their solitary cells at the prison, Bonnie goes undercover as an inmate at the penitentiary in question.
Michael, RC and even Bonnie use K.I.T.T. as an alibi to visit Chicago instead of doing a mission in Detroit. RC wants to catch blind singer Charley Conner's performance at his old friend Josh Bevin's bar. But Bevins' is on the receiving end of a beating by some thugs hired by construction overseer E.G. Sanford. To complicate matters, RC refuses to believe that his childhood friend and hero Keith is leading the enforcers. Meanwhile K.I.T.T. hooks up with a bunch of kids who show considerable music talent and decides to coach them, despite the fact that the car is quite...