Renowned adventurer Charlie Granger is murdered within the compounds of the Foundation. Michael and Kitt are send to protect Granger's estranged daughter Katherine who's locket hold the key to finding his hidden treasure.
Michael investigates a series of robberies in the small town of Vista Beach where an old acquaintance of Devon's runs an Art & Framing shop. The main suspects are a gang of drag racers because the thefts always happen during their weekend escapades.
April's adopted niece Becky needs a bone marrow transplant within 72 hours to stay alive. Mike tracks down the only available donor, Julio Rodriguez, a gang-member who is wanted for the murder of a gang leader.
Adrienne St. Clair has rebuild Goliath and springs Garthe Knight out of prison. Next they kidnap Devon and April from Foundation HQ in order to lure Michael and Kitt into a trap. Adrienne wants to install Kitt's CPU into Goliath, but Garthe is only interested in getting revenge on Michael.
Cameron Zachary, the man who ordered the death of Michael Long three years earlier, finds out Long is now going by the name of Michael Knight and sets out to destroy him once and for all, as well as get his hands on the Knight Industries Two Thousand. Meanwhile, an unsuspecting Michael is investigating the theft of a talking teddy bear toy design.
Michael and Kitt join forces with an agile freelance agent called David Dalton to investigate the death of a government agent near the Mexican border. Dalton leads the investigation and stays close to Joanna St. John in order to protect her.
Michael investigates the death of Greg Noble, lead singer of the rock and roll band 'Class Action' only to discover the lead singer is his lost love Stevie March. He takes Noble's place in the band to protect Stevie and find the murderer.
C.J. Jackson, the man who murdered Michael's predecessor at the Foundation, Ken Franklin breaks out of jail with help from a Self destruct robot disguised as a radio and a drone car. The masterminds behind his escape, David Halston and Margo Sheridan, are gathering a team to stage a break into a San Francisco vault. Michael and Devon ask Bonnie, who is studying at the university there to help them on this case. Her mentor at the university just happens to be David Halston.
A collection of diamonds is stolen from a Foundation sponsored charity auction. Michael and Kitt follow one of the thieves to the Monestary of the Grape in Napa. Here a plastic surgeon is providing criminals with new faces for a percentage of their takings.
A cheerleader named Stacy Courtney gets severely injured during an illegal drag race called Banzai-running. As she happens to be the daughter of Michael former partner on the L.A. police force, he decides to investigate. It soon leads him and K.I.T.T. to the owner of Michael's favorite football team, the Cougars.
Bonnie has just moved into a new apartment. Next door a rowdy party is going on two days before Halloween. She appears to witness a woman being strangled by someone wearing a gorilla costume but passes out. When Bonnie calls in help from the Foundation, at first it all seems to have been a fever induced hallucination on her part. Is it all in her mind or will Bonnie be the next victim come Halloween?
K.I.T.T.'s bad tempered prototype K.A.R.R. is found buried in the sand by mechanic John Stanton and his girlfriend Mandy. K.A.R.R. convinces Stanton to replace his damaged parts and give him a new look. Then he sets out to take his revenge on K.I.T.T. and Michael Knight. After turbo boosting into the Foundation's semi, John and K.A.R.R. take possession of an improved laser Bonnie was preparing for K.I.T.T. to use against his evil twin.
Michael is suspended from FLAG after a bag of heroin is found in his pocket. He contacts the main suspect he was after, LaSalle, in an attempt to clear his name. However, LaSalle orders Knight to steal K.I.T.T. from the Foundation and use him to steal a dangerous nerve-gas.
While Michael Knight and K.I.T.T. are on a case to stop the sale of deadly chemicals, a young dancer is inadvertently killed by toxic gas. Michael becomes determined to capture the criminals behind this new poison, but they are equally adamant to get rid of Knight by feeding him their deadly concoction.
K.I.T.T. gets electrocuted during a chase and loses his memory. After he and Michael get separated, K.I.T.T. befriends a young boy named Doug Wainwright. Unfortunately, the two crooks Michael and K.I.T.T. were chasing think Doug can identify them and decide to go after the boy.
A criminal known as 'The Chameleon' uses his gift as a master of disguise to escape on the way to a court hearing. He contacts Armand Pressler for one last job and plans to take his revenge on the man who put him in jail two years earlier, Michael Knight. So, in order to catch the Chameleon red handed, Michael takes on a guise as well, that of soldier of fortune 'Jack Smith'.