Throughout the series' run, exterior establishment shots of the Keaton home were never used in any of the episodes, which is very unusual for a family sitcom. The vast majority of all scenes were played out in the kitchen.
Mallory's boyfriend Nick was only intended to be a "One Shot" character. Scott Valentine made a strong impression on both the show's audience and producers resulting in Nick becoming a recurring character on the series. Nick proved to be so popular that Producers tried to spin him off into his own series, though the pilot never sold.
When Meredith Baxter became pregnant during the hiatus between the second and third seasons, her pregnancy was written into the show. However, she still was written out of several episodes after giving birth to twins in real life.
Michael J. Fox's first audition was deemed terrible by 'Gary Goldberg' because Fox came off too smart-aleck. Casting director 'Judith Wiener' really liked Fox and begged Goldberg to see him a second time. Fox took a different approach, the audition went great, and Fox was offered the part.
In one of his autobiographies, Michael J. Fox said that for at least ten years after his marriage to Tracy Pollan, the two couldn't get on a dance floor anywhere in the country without someone starting to play the 1981 song "At This Moment" by Billy Vera & The Beaters because of its strong association with the romance storyline between Fox's and Pollan's characters Alex and Ellen.
The series was intended to be a starring vehicle for Meredith Baxter and Michael Gross. As a result, the show's initial focus was more on the parents, with the kids more as background characters. The kids, Alex in particular, quickly came to gain a more equal, and eventually greater focus as Michael J. Fox established himself as the series break out star.
The show was a long-time staple of NBC's "Must See TV" Thursday night lineup. After season 5, the show moved from Thursday night following "The Cosby Show" to Saturday night. The show dropped from second place in the ratings to #17 due to move. The ratings declined even further in season 7 and the show was canceled.
Michael Gross once stated in an interview that he didn't feel that Steven Keaton had much dimension or depth until the character of Nick was added. He cited this addition as a major reason for staying on the show,
In March 2008, creator Gary David Goldberg wrote an essay for The New York Times speculating about what Alex Keaton's political beliefs would be now. Goldberg said that Keaton, as a "true Conservative Republican," would probably no longer feel comfortable in the Republican Party of the late 2000s, "a party whose legacy will include Terri Schiavo and Hurricane Katrina, [and]...waging war against science." Goldberg said that Keaton would have supported McCain in 2000 but no obvious candidate in the 2008 race. He also said that he and Michael J. Fox have different ideas about Keaton's current career; Goldberg thinks Keaton is a pro bono lawyer for the Children's Defense Fund, while Fox believes Keaton is finishing a prison sentence.
An episode set to air shortly before the 1988 Presidential Election was to have featured a scene showing Alex's bedroom full of George Bush campaign posters and related items. The scene was dropped as NBC felt it could be viewed as overtly political and potentially violated Equal Time laws. Instead a scene was shown after the election where Alex hung up and admired a poster of Bush in the living room to celebrate his victory.
Alex and Ellen's Love Theme was At This Moment by Billy Vera and The Beaters. The song was originally recorded and released in 1981 and went largely unnoticed. After being featured on the series, the single was re-released in the Fall of 1986, and reached Number One on the Billboard Top 100 Pop Chart in early 1987.
The political themes were heavily emphasized in early seasons of the series. However, as the show progressed and the focus moved on Alex and the children, the political themes were downplayed or used in a more light hearted manner in later seasons.
In the show, Meredith Baxter Birney and Michael Gross play extreme liberal activists who show annoyance towards their son Alex's love of Richard Nixon. However in All the President's Men (1976), Birney plays the wife of a Richard Nixon employee.
Meredith Baxter at times was rumored to have wanted to leave the series. This was said to be due over tensions between her and Michael J Fox, as Fox had largely usurped the show's intended focus away from Baxter and Michael Gross. Baxter and Fox have indicated that there was nothing to the reports over any feuds or tension between them.