The producers originally wanted Matthew Broderick to play Alex P. Keaton, but the actor had to decline the role when his father became terminally ill. Ironically, Broderick's father James Broderick played Meredith Baxter's father on the drama Family.
The show was modeled after producer Gary David Goldberg and wife Diane's real-life experiences as former 'hippies' transforming into suburban family life.
Michael J. Fox added the P. in Alex P. Keaton as an ad-lib in his audition, the writers loved it and kept it. Michael J. Fox almost didn't get the role of Alex - due to the fact that NBC exec Brandon Tartikoff didn't find it believable that Meredith Baxter and Michael Gross would have a son that was so short.
When Meredith Baxter became pregnant during the hiatus between the second and third seasons, her pregnancy was written into the show. However, she still was written out of several episodes after giving birth to twins in real life.
Michael J. Fox's first audition was deemed terrible by 'Gary Goldberg' because Fox came off too smart-aleck. Casting director 'Judith Wiener' really liked Fox and begged Goldberg to see him a second time. Fox took a different approach, the audition went great, and Fox was offered the part.
Throughout the series' run, exterior establishment shots of the Keaton home were never used in any of the episodes, which is very unusual for a family sitcom. The vast majority of all scenes were played out in the kitchen.
In March 2008, creator Gary David Goldberg wrote an essay for The New York Times speculating about what Alex Keaton's political beliefs would be now. Goldberg said that Keaton, as a "true Conservative Republican," would probably no longer feel comfortable in the Republican Party of the late 2000s, "a party whose legacy will include Terri Schiavo and Hurricane Katrina, [and]...waging war against science." Goldberg said that Keaton would have supported McCain in 2000 but no obvious candidate in the 2008 race. He also said that he and Michael J. Fox have different ideas about Keaton's current career; Goldberg thinks Keaton is a pro bono lawyer for the Children's Defense Fund, while Fox believes Keaton is finishing a prison sentence.
In one of his autobiographies, Michael J. Fox said that for at least ten years after his marriage to Tracy Pollan, the two couldn't get on a dance floor anywhere in the country without someone starting to play the 1981 song "At This Moment" by Billy Vera & The Beaters because of its strong association with the romance storyline between Fox's and Pollan's characters Alex and Ellen.
Mallory's boyfriend Nick was only intended to be a "One Shot" character. Scott Valentine made a strong impression on both the show's audience and producers resulting in Nick becoming a recurring character on the series. Nick proved to be so popular that Producers tried to spin him off into his own series, though the pilot never sold.
Michael Gross made a crossover appearance as Steven Keaton on the short lived NBC Sitcom Day by Day, which like Family Ties was created and produced by Gary David Goldberg.
The series was intended to be a starring vehicle for Meredith Baxter and Michael Gross. As a result, the show's initial focus was more on the parents, with the kids more as background characters. The kids, Alex in particular, quickly came to gain a more equal, and eventually greater focus as Michael J. Fox established himself as the series break out star.
An episode set to air shortly before the 1988 Presidential Election was to have featured a scene showing Alex's bedroom full of George Bush campaign posters and related items. The scene was dropped as NBC felt it could be viewed as overtly political and potentially violated Equal Time laws. Instead a scene was shown after the election where Alex hung up and admired a poster of Bush in the living room to celebrate his victory.
Alex and Ellen's Love Theme was At This Moment by Billy Vera and The Beaters. The song was originally recorded and released in 1981 and went largely unnoticed. After being featured on the series, the single was re-released in the Fall of 1986, and reached Number One on the Billboard Top 100 Pop Chart in early 1987.