While on holiday in Venice, DM and Penfold stumble upon a fiendish plot of Greenback's to raise buildings all over Europe and lure all tourists to his museum of Barry Mannilow album covers. Colonel K's office has arranged transport for them aboard the Orient Express, but Greenback has also charted the train for the Euro Master Crooks convention in Paris.
Greenback seeks a truce with Dangermouse to save the Earth from being attacked by an alien army. They agree to meet on Greenback's space station, but Dangermouse and Penfold are unaware they are flying into a trap.
Dr. Frankenstoat has constructed a fiendish device to make electric Vampoids infused with Count Duckula's personality. Danger Mouse infiltrates his castle intend on destroying the machine, but Penfold pushes the start button, releasing a flock of bats.
Top secret blueprints for a world shattering device have been stolen from Puttinghamdown Research station by Mac the Fork. He teams up with Dudley Poyson to build it as Dangermouse and Penfold race to Glasgow to stop them.