DM and Penfold are taking a holiday in New York provided by the nice folks at the FBI. Doctor Augustus P. Crumhorn III takes the opportunity to get his revenge on Danger Mouse by swallowing his transformation pills and posing as a terminally cute young girl who claims her father has been kidnapped.
Penfold is stuck in one of Danger Mouse's spare suits. The countries in central Europe have all changed places thanks to a massive earthquake. DM and PF head for Bratislowakia (after the latter finally unlocks the none sticking self locking zip fastener on the formers spare suit). Once there, they find that not only countries, but people too are swapping places, thanks to the swapping stone of Mellikan the magician.
A massive allergy attack caused by an army of remote controlled pillows is causing havoc across London. Not even Danger Mouse and Penfold are immune to this latest scheme masterminded by Baron Silas Greenback.