Despite the raw and explicit content in this film, this is in part false. The main lead roles, played by British actors and actresses, had fairly successful careers despite their contribution to the project. After this film, Malcolm McDowell (Caligula) had no other major roles, but this was because the British film industry collapsed, forcing him to flee to America to continue working. Peter O' Toole (Tiberius) returned to films with triumphant performances in The Stunt Man (1980) and My Favorite Year (1982). Needless to say, Helen Mirren went on to have an illustrious career as one of the most prestigious English actors and won an Oscar for "The Queen" (2006).
As for the supporting cast, Teresa Ann Savoy (Drusilla) simply grew tired of her career not moving beyond erotically themed films and retired from acting and currently lives in Italy. Other actors, such as John Steiner (Longinus), never fully established a strong acting career in the first place and also retired from acting in the early 1990s. However some of the Italian actors remained successful performers in the Italian film industry, like Adriana Asti, Mirella D'Angelo, and Paolo Bonacelli. Some of the Italian cast members weren't even professional actors at all, like Guido Mannari, who only got cast as Macro because at the time he was romantically involved with the film's producer, Franco Rossellini.
On the other hand, the tragic late Anneka Di Lorenzo's career suffered as a direct result of the extra hardcore lesbian footage that "Penthouse" publisher Bob Guccione filmed with her participation during post-production. In 1988 she sued Guccione on charges of sexual slavery and defamation. Anneka won a $4,000,000 judgment when the trial was over and finished, but lost most of it due to numerous lawyer fees and successful appeals by the other party. She later went on to have a low-key life as a nursing assistant and died under mysterious circumstances in January of 2011.