There is a bomb somewhere in the hospital set to go off at midnight, the night of Trapper's 10th anniversary as chief of surgery. The bomb squad can't find it, and the man who planted it is dying from bullet wounds.
Gloria falls for a man in a wheelchair - who happens to already have a wife. Gonzo firmly believes that he can cure a disabled man with surgery, but said patient is against the operation. Trapper resents Starch labelling him "predictable", and decides to do something about it.
A former patient who recovered from terminal cancer using a holistic approach he devised has written a book and is looking for converts. The patient convinces a lupus patient to stop all medical treatment, and nearly allows her to die before accepting that she needs help he cannot give her. Meanwhile, SFM admits a gang member who likes to draw graffiti and does so on hospital property.
Stanley thinks he has finally found the love of his life in the hospital's excellent new neurosurgeon, until he learns how she made the money to get through medical school. A sleazy reporter looking for dirt around the hospital gets more than he bargained for.
At first Trapper is not concerned when an old friend starts to behave erratically, but Gonzo suspects that something is wrong, especially when the doctor freezes during an emergency. Meanwhile, San Francisco Memorial is flooded with patients from a nearby hospital, after it is damaged by fire.
Gonzo is suspicious of a young Korean man who comes to the hospital claiming to be the long-lost son of Trapper. A woman with a history of faking illness is surprised when she is diagnosed with a rare disease.
Gonzo and the staff decide to start a hot-line for people to anonymously call with their problems. Trapper takes a risk by bringing in a retired doctor with an alcohol problem to help perform a rare eye operation.
A controlling millionaire publisher gives the hospital a large donation in exchange for Gonzo watching over his daughter who has a rare blood disorder that needs round-the-clock care and is smitten with Dr. Gates. Trapper must find a replacement for Starch who has gotten married and retired.
When Gonzo learns that an old classmate has put her health and sanity at risk by following a strict diet which encourages the use of diuretics, he goes after the well-respected doctor who founded the diet.