A couple desperate for a child adopts a black-market baby, only to discover that the infant is addicted to heroin and has a heart condition. Stanley recruits Trapper and Gonzo to join him in a relay race against Bay General.
Gloria's brother Brian flies in from Texas for a visit. He manages to turn Gloria's life upside down. As a result of his drinking problem, her work at the hospital suffers and she is given an official warning. Meanwhile, a patient is trying to set Trapper up with her daughter.
A man is brought in who claims to be writing a book on the KKK. Later someone comes and sees him and threatens him. When Gonzo tries to talk to him about what he said, he denies it. Later Gonzo finds in his things that he's telling the truth and that one of the hospital's brilliant doctors is the head.
San Francisco Memorial Hospital is endeavouring to put into place a co-operative care program, due to Arnold Slocomb and the Board of Directors' budget cuts. Mrs Fitch and her niece, Liza, are the perfect candidates, if Mrs. Fitch would only accept Liza's help.
A female prisoner gives birth to a premature baby, who is rushed to SFM for care. The mother, upset at not being allowed to be with her child, beats the prison warden who refused to arrange for her to be taken to the hospital.
A surgeon and friend of Trapper comes to operate on someone he knows. But he's experiencing having visions of actual things. He is told that because of head trauma he sustained, he has gained a sixth sense which he doesn't believe in. And it also causes tension between him and his wife, and she turns to Gonzo whom she knows for solace.
A young man admitted to the hospital following an accident informs the staff that his name is "42" and that he is an alien who is stranded on Earth. While building a transmitter to contact his home planet, 42 befriends a sick and lonely woman.
A mentally disabled man who works at the hospital is able to make friends with a crotchety old hermit who is dying of cancer, but gets embarrassed and quits his job when he misinterprets Gloria's feelings for him.
A woman who devotes her life to getting teenage hookers off the street is badly beaten by a pimp. Gonzo's disgust at their apparent disinterest convinces the girls to get revenge on the attacker, while having two prostitutes show up at his house seriously hampers Trapper's love life.
A doctor that comes to SFM with an accident patient is so good that Slocum wants to bring him on staff, but he runs into a problem - the schools that the man claims to have trained at have never heard of him. Jackpot is frustrated by a Jane Doe with a high fever and some unusual symptoms.
Ernie is engaged to be married, but begins to have second thoughts when her fiancé expects her to take all of the responsibility for the house, his five children and their relationship while he relaxes after work and serves as nothing more than a playmate to his out-of-control kids.
A 74-year-old woman who is admitted with a blocked artery in her leg has another problem - she is hooked on prescription medications. When Trapper and Gonzo discover that her doctor is responsible, and treats all his patients the same way, they plot to drive him out of business.
Jackpot is put in charge of Emergency Services while Trapper, Gonzo and Stanley attend a medical conference in Mexico. South of the border, Trapper falls in love with another doctor, but they may have too much in common for the romance to last.
Jackpot convinces several of the staff to invest in a promising young boxer he is managing, but after the fighter kills his opponent in his first professional match he begins to suffer mysterious injuries that may keep him out of the ring permanently.
A rumor that Trapper may be leaving SFM for a hospital in Boston has several other staff considering new positions. After 72 hours on duty and the loss of a patient, Stanley is displaying psychotic symptoms, and ends up in jail.
A man who needs a bone marrow transplant to survive claims that he has no relatives that can serve as donors. However, Gonzo soon discovers that the truth is a little more complicated: the man is in the Witness Protection Program, and cannot safely have contact with his family.
A flower salesgirl, who works on the street, wakes up one day at the hospital. The girl is very ill yet refuses to be treated since she considers that doctors are Satan's henchmen. The estranged mother of a cult member has the girl kidnapped from the hospital.