When an employee from a local nuclear power plant is admitted to SFM with signs of radiation poisoning, Gonzo cannot understand why it appears that nothing is being done to protect other workers from exposure. Meanwhile, Riverside must contend with a very distrusting Gypsy.
A persistent swain of his ex-wife, Melanie, causes both professional and romantic turmoil for Trapper, as his hopes for a reconciliation dwindle when she asks him to treat her new fiancé. Meanwhile, Stanley is determined to get rid of the "Titanic".
A local street person known as "Harry the Hinge" is admitted to SFM with kidney failure. Meanwhile, Trapper and Gonzo decide to protest a decision to divert free-clinic funds to the pet project of a one of the hospital's major benefactors.
A boy is brought in and he calls his father to come. He offers to donate blood if he needs it. But tests reveal the man is not the boy's father. He tells them he found him a few years ago and took him in. And he eventually would think of him as his son. Trapper tells the authorities and they learns that the boy ran away from his mother. When she comes he doesn't want to be with her. But the man doesn't have any rights so he tells him he has to go with her. And he becomes catatonic.
There is a bomb somewhere in the hospital set to go off at midnight, the night of Trapper's 10th anniversary as chief of surgery. The bomb squad can't find it, and the man who planted it is dying from bullet wounds.
Gloria falls for a man in a wheelchair - who happens to already have a wife. Gonzo firmly believes that he can cure a disabled man with surgery, but said patient is against the operation. Trapper resents Starch labelling him "predictable", and decides to do something about it.
A former patient who recovered from terminal cancer using a holistic approach he devised has written a book and is looking for converts. The patient convinces a lupus patient to stop all medical treatment, and nearly allows her to die before accepting that she needs help he cannot give her. Meanwhile, SFM admits a gang member who likes to draw graffiti and does so on hospital property.
Stanley thinks he has finally found the love of his life in the hospital's excellent new neurosurgeon, until he learns how she made the money to get through medical school. A sleazy reporter looking for dirt around the hospital gets more than he bargained for.
At first Trapper is not concerned when an old friend starts to behave erratically, but Gonzo suspects that something is wrong, especially when the doctor freezes during an emergency. Meanwhile, San Francisco Memorial is flooded with patients from a nearby hospital, after it is damaged by fire.
Gonzo is suspicious of a young Korean man who comes to the hospital claiming to be the long-lost son of Trapper. A woman with a history of faking illness is surprised when she is diagnosed with a rare disease.
Gonzo and the staff decide to start a hot-line for people to anonymously call with their problems. Trapper takes a risk by bringing in a retired doctor with an alcohol problem to help perform a rare eye operation.